Evaluation of Cumulative Effect of Standard Triple Immunosuppression on Prevention of De Novo Donor Specific Antibodies (dnDSA) Production in Children after Kidney Transplantation-A Retrospective and Prospective Study.
TAC variability and concentration
Vasudev score
cumulative strength of immunosuppression
dnDSA
kidney transplantation
Journal
Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936
Informations de publication
Date de publication:
09 Dec 2021
09 Dec 2021
Historique:
received:
11
11
2021
revised:
06
12
2021
accepted:
07
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
De novo Donor Specific Antibodies (dnDSA) are associated with inferior graft outcomes. Standard immunosuppression is expected to prevent dnDSA production in low-risk patients. We have evaluated a cumulative effect of a triple immunosuppression (CNI/MMF/Pred), as well as TAC concentration and coefficient of variation on the incidence of dnDSA production. Overall, 67 transplanted patients were evaluated in retrospective (dnDSA for-cause;
Identifiants
pubmed: 34943360
pii: children8121162
doi: 10.3390/children8121162
pmc: PMC8700537
pii:
doi:
Types de publication
Journal Article
Langues
eng
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