Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on
Certika
ToF-SIMS imaging
anti-colonization
antifouling
antimicrobial peptide
antimicrobial surface
self-assembled monolayer
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
10 Dec 2021
10 Dec 2021
Historique:
received:
28
11
2021
revised:
07
12
2021
accepted:
08
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Medical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization.
Identifiants
pubmed: 34943728
pii: antibiotics10121516
doi: 10.3390/antibiotics10121516
pmc: PMC8698454
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Research Council of Norway
ID : 283272
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