Ascorbic Acid/Retinol and/or Inflammatory Stimuli's Effect on Proliferation/Differentiation Properties and Transcriptomics of Gingival Stem/Progenitor Cells.
Adolescent
Ascorbic Acid
/ pharmacology
Biomarkers
/ metabolism
Cell Differentiation
/ drug effects
Cell Lineage
/ drug effects
Cell Proliferation
/ drug effects
Colony-Forming Units Assay
Female
Gene Expression Profiling
Gene Expression Regulation
/ drug effects
Gingiva
/ pathology
Humans
Inflammation
/ genetics
Male
Mesenchymal Stem Cells
/ drug effects
RNA, Messenger
/ genetics
Tissue Donors
Transcriptome
/ drug effects
Vitamin A
/ pharmacology
Young Adult
beta Catenin
/ metabolism
ascorbic acid
gingiva
inflammation
retinol
stem cell
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 11 2021
25 11 2021
Historique:
received:
10
10
2021
revised:
16
11
2021
accepted:
18
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
21
1
2022
Statut:
epublish
Résumé
The present study explored the effects of ascorbic-acid (AA)/retinol and timed inflammation on the stemness, the regenerative potential, and the transcriptomics profile of gingival mesenchymal stem/progenitor cells' (G-MSCs). STRO-1 (mesenchymal stem cell marker) immuno-magnetically sorted G-MSCs were cultured in basic medium (control group), in basic medium with IL-1β (1 ng/mL), TNF-α (10 ng/mL) and IFN-γ (100 ng/mL, inflammatory-medium), in basic medium with AA (250 µmol/L) and retinol (20 µmol/L) (AA/retinol group) or in inflammatory medium with AA/retinol (inflammatory/AA/retinol group;
Identifiants
pubmed: 34943818
pii: cells10123310
doi: 10.3390/cells10123310
pmc: PMC8699152
pii:
doi:
Substances chimiques
Biomarkers
0
RNA, Messenger
0
beta Catenin
0
Vitamin A
11103-57-4
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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