Lauric Acid, a Dietary Saturated Medium-Chain Fatty Acid, Elicits Calcium-Dependent Eryptosis.
Benzamides
/ pharmacology
Calcium
/ metabolism
Dietary Fats
/ pharmacology
Eryptosis
/ drug effects
Extracellular Space
/ chemistry
Fatty Acids
/ pharmacology
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Hemolysis
/ drug effects
Homeostasis
/ drug effects
Humans
Imidazoles
/ pharmacology
Lauric Acids
/ pharmacology
Lipid Peroxidation
/ drug effects
Lymphocytes
/ drug effects
Neutrophils
/ drug effects
Oxidative Stress
/ drug effects
Phosphatidylserines
/ metabolism
Protein Carbonylation
/ drug effects
calcium
cardiovascular disease
eryptosis
hemolysis
lauric acid
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
received:
11
10
2021
revised:
20
11
2021
accepted:
28
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
7
1
2022
Statut:
epublish
Résumé
Cardiovascular diseases (CVD) are a leading cause of mortality worldwide, and dietary habits represent a major risk factor for dyslipidemia; a hallmark of CVD. Saturated fatty acids contribute to CVD by aggravating dyslipidemia, and, in particular, lauric acid (LA) raises circulating cholesterol levels. The role of red blood cells (RBCs) in CVD is increasingly being appreciated, and eryptosis has recently been identified as a novel mechanism in CVD. However, the effect of LA on RBC physiology has not been thoroughly investigated. RBCs were isolated from heparin-anticoagulated whole blood (WB) and exposed to 50-250 μM of LA for 24 h at 37 °C. Hemoglobin was photometrically examined as an indicator of hemolysis, whereas eryptosis was assessed by Annexin V-FITC for phosphatidylserine (PS) exposure, Fluo4/AM for Ca
Identifiants
pubmed: 34943896
pii: cells10123388
doi: 10.3390/cells10123388
pmc: PMC8699421
pii:
doi:
Substances chimiques
4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
0
Benzamides
0
Dietary Fats
0
Fatty Acids
0
Imidazoles
0
Lauric Acids
0
Phosphatidylserines
0
Glutathione Peroxidase
EC 1.11.1.9
Glutathione
GAN16C9B8O
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deanship of Scientific Research, King Saud University
ID : Vice Deanship of Scientific Research Chairs (DSRVCH)
Références
Am Fam Physician. 2004 Jun 1;69(11):2599-606
pubmed: 15202694
Mol Med Rep. 2016 Mar;13(3):2606-12
pubmed: 26821085
J Inherit Metab Dis. 1993;16(4):648-69
pubmed: 8412012
QJM. 2006 Dec;99(12):851-62
pubmed: 17121766
Am J Clin Nutr. 2020 Dec 10;112(6):1642-1652
pubmed: 33053149
Annu Rev Nutr. 1996;16:33-50
pubmed: 8839918
Chemotherapy. 2013;59(3):214-24
pubmed: 24356281
Prog Lipid Res. 2013 Oct;52(4):354-73
pubmed: 23624223
Eur Heart J. 2007 Nov;28(22):2763-9
pubmed: 17766282
Nephrol Dial Transplant. 2000;15 Suppl 3:14-8
pubmed: 11032352
Trends Cardiovasc Med. 2001 Apr-May;11(3-4):162-5
pubmed: 11686007
Cell Signal. 2012 May;24(5):981-90
pubmed: 22286106
Biochim Biophys Acta. 1969;183(3):499-511
pubmed: 4898480
Nutrients. 2019 Aug 28;11(9):
pubmed: 31466350
Atherosclerosis. 1999 Jun;144(2):285-301
pubmed: 10407490
Int J Biochem. 1986;18(9):771-5
pubmed: 3758459
Eur Heart J. 2007 Nov;28(22):2699-700
pubmed: 17933757
Cardiovasc Res. 2021 Jul 06;:
pubmed: 34229346
Arch Pharm Res. 2013 Jul;36(7):912-7
pubmed: 23512775
Eur Heart J. 2000 Apr;21(7):515-20
pubmed: 10775006
Oxid Med Cell Longev. 2020 May 14;2020:5732956
pubmed: 32509147
J Am Diet Assoc. 2008 Feb;108(2):287-331
pubmed: 18237578
Eur Heart J. 2000 Oct;21(19):1614-20
pubmed: 10988014
Am J Clin Nutr. 1994 Feb;59(2):371-7
pubmed: 8310987
Cell Physiol Biochem. 2017;43(2):431-444
pubmed: 28922657
Clin Nutr. 2004 Aug;23(4):721-32
pubmed: 15297111
Biomed Res Int. 2018 Jan 3;2018:9405617
pubmed: 29516014
Circulation. 2002 Mar 26;105(12):1485-90
pubmed: 11914259
Circ Heart Fail. 2013 Sep 1;6(5):964-9
pubmed: 23926204
Toxicon. 2021 Aug;199:41-48
pubmed: 34081931
Oxid Med Cell Longev. 2019 May 9;2019:5028181
pubmed: 31210841
Arterioscler Thromb. 1991 Nov-Dec;11(6):1700-11
pubmed: 1931871
Early Hum Dev. 2001 Nov;65 Suppl:S95-S101
pubmed: 11755040
Biology (Basel). 2020 Oct 22;9(11):
pubmed: 33105887
J Food Biochem. 2021 Apr;45(4):e13710
pubmed: 33749832
BMJ. 2018 Jun 13;361:k2139
pubmed: 29898882
Isr Med Assoc J. 2004 Jan;6(1):16-8
pubmed: 14740503
Cell Physiol Biochem. 2016;39(5):1977-2000
pubmed: 27771701
BMJ. 2019 Jul 3;366:l4137
pubmed: 31270106
Am J Clin Nutr. 1992 Nov;56(5):895-8
pubmed: 1415008
Front Physiol. 2021 Feb 23;12:638027
pubmed: 33708142
Ann Transl Med. 2017 Aug;5(16):326
pubmed: 28861423
Methods Mol Biol. 2021;2326:155-165
pubmed: 34097267
Free Radic Biol Med. 1999 Nov;27(9-10):916-21
pubmed: 10569624
J Nutr. 1995 Mar;125(3):466-73
pubmed: 7876922
Biomolecules. 2020 Jul 30;10(8):
pubmed: 32751513
N Engl J Med. 1991 Aug 8;325(6):373-81
pubmed: 2062328
J Cell Mol Med. 2010 Apr;14(4):840-60
pubmed: 19754673
J Lab Physicians. 2020 Dec;12(4):239-243
pubmed: 33390672
Rejuvenation Res. 2013 Jun;16(3):179-84
pubmed: 23442131
Am J Epidemiol. 2003 Nov 1;158(9):844-51
pubmed: 14585762
Nutrients. 2019 Sep 04;11(9):
pubmed: 31487802
Cardiovasc Res. 2013 Apr 1;98(1):37-46
pubmed: 23341574
Clin Sci (Lond). 2006 Nov;111(5):307-17
pubmed: 16737441
Biol Pharm Bull. 2021 Mar 1;44(3):372-378
pubmed: 33431739
Kardiol Pol. 2018;76(4):713-722
pubmed: 29537483
Int J Occup Med Environ Health. 2021 Aug 30;:
pubmed: 34524276
Biochim Biophys Acta. 1975 Nov 17;413(1):65-78
pubmed: 127620
J Am Coll Cardiol. 2005 Jun 7;45(11):1802-6
pubmed: 15936609
JPEN J Parenter Enteral Nutr. 2000 Mar-Apr;24(2):113-8
pubmed: 10772192
Toxicol Appl Pharmacol. 2019 May 1;370:36-43
pubmed: 30880218
Am J Clin Nutr. 2018 Nov 1;108(5):1069-1091
pubmed: 30475962
Biochem Biophys Res Commun. 2005 Dec 23;338(3):1368-73
pubmed: 16263083
Am J Cardiol. 2003 Feb 6;91(3A):7A-11A
pubmed: 12645638
Essays Biochem. 2015;59:43-69
pubmed: 26504250
Circulation. 1999 Feb 2;99(4):591-5
pubmed: 9927409
Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1183-92
pubmed: 16910766
J Nutr. 2001 Feb;131(2):242-5
pubmed: 11160540
Blood. 2005 Dec 15;106(13):4034-42
pubmed: 16051738
BMC Cardiovasc Disord. 2009 Nov 12;9:51
pubmed: 19909540
Antioxid Redox Signal. 2017 Nov 10;27(14):1083-1124
pubmed: 28816059
Sensors (Basel). 2011;11(2):1744-55
pubmed: 22319379
Cell Death Discov. 2017 Sep 18;3:17063
pubmed: 28924490
Med Hypotheses. 2004;62(6):966-9
pubmed: 15142658
Diabetes Care. 2011 Jan;34(1):162-7
pubmed: 20929994
Am J Clin Nutr. 2003 May;77(5):1146-55
pubmed: 12716665
Hum Exp Toxicol. 2019 Jul;38(7):753-761
pubmed: 30942101
Chem Biol Interact. 1991;79(3):335-47
pubmed: 1717169
Toxicol In Vitro. 2002 Dec;16(6):741-7
pubmed: 12423658
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 15;1019:178-90
pubmed: 26706659
Cell Biochem Funct. 1998 Dec;16(4):253-9
pubmed: 9857487
Am J Clin Nutr. 1996 Jun;63(6):897-903
pubmed: 8644684
J Korean Med Sci. 2016 Jan;31(1):98-105
pubmed: 26770044
Eur J Clin Invest. 2015 Dec;45(12):1316-24
pubmed: 26479159
Chemosphere. 2019 Aug;229:103-111
pubmed: 31078025
J Chemother. 2021 Aug 19;:1-11
pubmed: 34410893
J Food Biochem. 2021 Nov;45(11):e13977
pubmed: 34664287
Circulation. 2021 Feb 23;143(8):e254-e743
pubmed: 33501848
Am J Clin Nutr. 2011 Sep;94(3):847-53
pubmed: 21795440
Food Chem Toxicol. 1995 Jul;33(7):601-17
pubmed: 7628797
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021
pubmed: 33309175