CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34
Acute Disease
Antigens, CD34
/ metabolism
Cytomegalovirus
/ physiology
Cytomegalovirus Infections
/ genetics
Female
Gene Frequency
/ genetics
Glucuronidase
/ genetics
Graft vs Host Disease
/ genetics
Granulocyte Colony-Stimulating Factor
/ pharmacology
Hematopoietic Stem Cell Mobilization
Humans
Male
Polymorphism, Single Nucleotide
/ genetics
Risk Factors
Tissue Donors
CMV
G-CSF-mobilization
HPSE gene
SNPs
acute GVHD
allogeneic HSCT
enhancer
insulator
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
received:
01
11
2021
revised:
02
12
2021
accepted:
07
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
6
1
2022
Statut:
epublish
Résumé
Heparanase is an endo-β-glucuronidase that is best known for its pro-cancerous effects but is also implicated in the pathogenesis of various viruses. Activation of heparanase is a common strategy to increase viral spread and trigger the subsequent inflammatory cascade. Using a Single Nucleotide Polymorphisms (SNP)-associated approach we identified enhancer and insulator regions that regulate HPSE expression. Although a role for heparanase in viral infection has been noticed, the impact of HPSE functional SNPs has not been determined. We investigated the effect of cytomegalovirus (CMV) serostatus on the involvement of HPSE enhancer and insulator functional SNPs in the risk of acute graft versus host disease (GVHD) and granulocyte-colony stimulating factor related CD34
Identifiants
pubmed: 34943994
pii: cells10123489
doi: 10.3390/cells10123489
pmc: PMC8700738
pii:
doi:
Substances chimiques
Antigens, CD34
0
Granulocyte Colony-Stimulating Factor
143011-72-7
heparanase
EC 3.2.1.-
Glucuronidase
EC 3.2.1.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : grant 1021/19
Organisme : Israel Cancer Research Fund
ID : no
Organisme : the DKFZ-MOST cancer research program
ID : no
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