NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression.
Alzheimer’s disease
Simoa-immunoassays
biomarker
blood
cerebrospinal fluid
neurodegeneration
neurofilament light chain
prion disease
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 12 2021
13 12 2021
Historique:
received:
10
11
2021
revised:
04
12
2021
accepted:
08
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
22
1
2022
Statut:
epublish
Résumé
This study investigates the diagnostic and prognostic potential of different forms of tau in biofluids from patients with Creutzfeldt-Jakob disease (CJD). Extracellular tau, which is molecularly heterogeneous, was measured using ultra-sensitive custom-made Simoa assays for N-terminal (NT1), mid-region, and full-length tau. We assessed cross-sectional CSF and plasma from healthy controls, patients with Alzheimer's disease (AD) and CJD patients. Then, we evaluated the correlation of the best-performing tau assay (NT1-tau) with clinical severity and functional decline (using the MRC Prion Disease Rating Scale) in a longitudinal CJD cohort (
Identifiants
pubmed: 34944022
pii: cells10123514
doi: 10.3390/cells10123514
pmc: PMC8700417
pii:
doi:
Substances chimiques
Biomarkers
0
Neurofilament Proteins
0
neurofilament protein L
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Alzheimer's Drug Discovery Foundation
ID : 201809-2016862
Organisme : Alzheimer’s Association
ID : ADSF-21-831377-C
Organisme : Medical Research Council
ID : MC_UU_00024/1
Pays : United Kingdom
Organisme : Alzheimer's Society
ID : AS-CTF-16b-007
Pays : United Kingdom
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG ME 4858/1-1
Organisme : AD Strategic Fund
ID : ADSF-21-831376-C
Organisme : Alzheimer's Association
ID : ZEN-18-533290
Pays : United States
Organisme : European Research Council
ID : 681712
Pays : International
Organisme : Stiftelsen för Gamla Tjänarinnor
ID : FO2019-0228
Organisme : Medical Faculty of Tuebingen University
ID : 459-0-0
Organisme : Alzheimer's Drug Discovery Foundation
ID : 20161205
Organisme : Medical Research Council
ID : MC_UU_00024/9
Pays : United Kingdom
Organisme : Alzheimer’s Association
ID : ADSF-21-831381-C
Organisme : Swedish Research Council
ID : #2018-02532
Organisme : NIA NIH HHS
ID : P30 AG062429
Pays : United States
Organisme : European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement
ID : 860197
Organisme : Medical Research Council
ID : G0400713
Pays : United Kingdom
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