Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms.

FCoV FIPV FeHV-1 innate immunity

Journal

Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614

Informations de publication

Date de publication:
14 Dec 2021
Historique:
received: 24 10 2021
revised: 11 12 2021
accepted: 12 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

Over time, feline viruses have acquired elaborateopportunistic properties, making their infections particularly difficult to prevent and treat. Feline coronavirus (FCoV) and feline herpesvirus-1 (FeHV-1), due to the involvement of host genetic factors and immune mechanisms in the development of the disease and more severe forms, are important examples of immune evasion of the host's innate immune response by feline viruses.It is widely accepted that the innate immune system, which providesan initial universal form of the mammalian host protection from infectious diseases without pre-exposure, plays an essential role in determining the outcome of viral infection.The main components of this immune systembranchare represented by the internal sensors of the host cells that are able to perceive the presence of viral component, including nucleic acids, to start and trigger the production of first type interferon and to activate the cytotoxicity by Natural Killercells, often exploited by viruses for immune evasion.In this brief review, we providea general overview of the principal tools of innate immunity, focusing on the immunologic escape implemented byFCoVand FeHV-1 duringinfection.

Identifiants

pubmed: 34944324
pii: ani11123548
doi: 10.3390/ani11123548
pmc: PMC8698202
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Paolo Capozza (P)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Annamaria Pratelli (A)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Michele Camero (M)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Gianvito Lanave (G)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Grazia Greco (G)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Francesco Pellegrini (F)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Maria Tempesta (M)

Department of Veterinary Medicine, University of Bari Aldo Moro, 70010 Valenzano, Italy.

Classifications MeSH