Streptozotocin-Induced Diabetes in a Mouse Model (BALB/c) Is Not an Effective Model for Research on Transplantation Procedures in the Treatment of Type 1 Diabetes.

C-peptide T1D animal model diabetic glucose mouse streptozotocin

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
29 Nov 2021
Historique:
received: 27 10 2021
revised: 23 11 2021
accepted: 25 11 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

Type 1 diabetes (T1D) is characterized by the destruction of over 90% of the β-cells. C-peptide is a parameter for evaluating T1D. Streptozotocin (STZ) is a standard method of inducing diabetes in animals. Eight protocols describe the administration of STZ in mice; C-peptide levels are not taken into account. The aim of the study is to determine whether the STZ protocol for the induction of beta-cell mass destruction allows for the development of a stable in vivo mouse model for research into new transplant procedures in the treatment of type 1 diabetes.

Identifiants

pubmed: 34944607
pii: biomedicines9121790
doi: 10.3390/biomedicines9121790
pmc: PMC8698562
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Centre for Research and Development
ID : STRATEGMED3/305813/2/NCBR/2017

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Auteurs

Michal Wszola (M)

Foundation of Research and Science Development, 01-793 Warsaw, Poland.

Marta Klak (M)

Foundation of Research and Science Development, 01-793 Warsaw, Poland.

Anna Kosowska (A)

Chair and Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warsaw, Poland.

Grzegorz Tymicki (G)

Foundation of Research and Science Development, 01-793 Warsaw, Poland.

Andrzej Berman (A)

Foundation of Research and Science Development, 01-793 Warsaw, Poland.

Anna Adamiok-Ostrowska (A)

Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.

Joanna Olkowska-Truchanowicz (J)

Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, 02-004 Warsaw, Poland.

Izabela Uhrynowska-Tyszkiewicz (I)

Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, 02-004 Warsaw, Poland.

Artur Kaminski (A)

Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, 02-004 Warsaw, Poland.

Classifications MeSH