The Identification of Prohibitin in the Rat Heart Mitochondria in Heart Failure.
astaxantin (AX)
heart failure (HF)
isoproterenol (ISO)
oxidative phosphorylation (OXPHOS)
oxidative stress
prohibitin (PHB)
rat heart mitochondria (RHM)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
29 Nov 2021
29 Nov 2021
Historique:
received:
15
11
2021
revised:
26
11
2021
accepted:
26
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Mitochondria are considered the main organelles in the cell. They play an important role in both normal and abnormal heart function. There is a supramolecular organization between the complexes of the respiratory chain (supercomplexes (SCs)), which are involved in mitochondrial respiration. Prohibitins (PHBs) participate in the regulation of oxidative phosphorylation (OXPHOS) activity and interact with some subunits of the OXPHOS complexes. In this study, we identified a protein whose level was decreased in the mitochondria of the heart in rats with heart failure. This protein was PHB. Isoproterenol (ISO) has been used as a compound to induce heart failure in rats. We observed that astaxanthin (AX) increased the content of PHB in rat heart mitochondria isolated from ISO-injected rats. Since it is known that PHB forms complexes with some mitochondrial proteins and proteins that are part of the complexes of the respiratory chain, the change in the levels of these proteins was investigated under our experimental conditions. We hypothesized that PHB may be a target for the protective action of AX.
Identifiants
pubmed: 34944609
pii: biomedicines9121793
doi: 10.3390/biomedicines9121793
pmc: PMC8699106
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 20-04-00131
Organisme : Russian Foundation for Basic Research
ID : 20-015-00072
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