Analyzing the Therapeutic Efficacy of Bis-Choline-Tetrathiomolybdate in the
ALXN-1840
Atp7b
D-penicillamine
WTX101
Wilson’s disease
bis-choline-tetrathiomolybdate
copper
laser ablation inductively coupled plasma mass spectrometry
therapy
trientine
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
08 Dec 2021
08 Dec 2021
Historique:
received:
04
11
2021
revised:
05
12
2021
accepted:
06
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Bis-choline-tetrathiomolybdate, introduced as WTX101 (now known as ALXN1840), is a first-in-class copper-protein-binding agent for oral therapy of Wilson's disease. In contrast to other decoppering agents such as trientine or D-penicillamine it acts by forming a tripartite complex with copper and albumin, thereby detoxifying excess liver and blood copper through biliary excretion. Preclinical animal experimentation with this drug was typically done with the alternative ammonium salt of tetrathiomolybdate, which is expected to have identical properties in terms of copper binding. Here, we comparatively analyzed the therapeutic efficacy of ALXN1840, D-penicillamine and trientine in lowering hepatic copper content in
Identifiants
pubmed: 34944677
pii: biomedicines9121861
doi: 10.3390/biomedicines9121861
pmc: PMC8698685
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : WE 2554/13-1, WE 2554/15-1, WE 2554/17-1
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