Metabolic Fatty Liver Disease in Children: A Growing Public Health Problem.
MAFLD
NAFLD
obesity
pediatric
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
14 Dec 2021
14 Dec 2021
Historique:
received:
12
11
2021
revised:
09
12
2021
accepted:
11
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Metabolic-associated fatty liver disease (MAFLD), previously called nonalcoholic fatty liver diseases (NAFLD), is one of the most important causes of chronic liver disease worldwide and will likely become the leading cause of end-stage liver disease in the decades ahead. MAFLD covers a continuum of liver diseases from fatty liver to nonalcoholic steatohepatitis (NASH), liver fibrosis/cirrhosis and hepatocellular cancer. Importantly, the growing incidence of overweight and obesity in childhood, 4% in 1975 to 18% in 2016, with persisting obesity complications into adulthood, is likely to be harmful by increasing the incidence of severe MAFLD at an earlier age. Currently, MAFLD is the leading form of chronic liver disease in children and adolescents, with a global prevalence of 3 to 10%, pointing out that early diagnosis is therefore crucial. In this review, we highlight the current knowledge concerning the epidemiology, risk factors and potential pathogenic mechanisms, as well as diagnostic and therapeutic approaches, of pediatric MAFLD.
Identifiants
pubmed: 34944730
pii: biomedicines9121915
doi: 10.3390/biomedicines9121915
pmc: PMC8698722
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE14-0019-02
Organisme : Agence Nationale de la Recherche
ID : ANR-19-CE14-0044-01
Organisme : Agence Nationale de la Recherche
ID : ANR-21-CE14-0015-03
Organisme : ARS PACA
ID : Allowance for specialized obesity centers
Organisme : Association Française pour l'Etude du Foie
ID : Charities
Organisme : Inserm
ID : INSERM Endowment
Références
Hepatobiliary Surg Nutr. 2021 Jun;10(3):337-349
pubmed: 34159161
Best Pract Res Clin Endocrinol Metab. 2016 Jun;30(3):385-95
pubmed: 27432073
Pediatr Obes. 2017 Dec;12(6):446-452
pubmed: 27350543
JAMA. 2011 Apr 27;305(16):1659-68
pubmed: 21521847
Biochimie. 2005 Jan;87(1):99-109
pubmed: 15733744
Children (Basel). 2021 Mar 23;8(3):
pubmed: 33806784
Front Endocrinol (Lausanne). 2020 Dec 14;11:597648
pubmed: 33384662
Cell Metab. 2018 Jan 9;27(1):22-41
pubmed: 28867301
Surg Obes Relat Dis. 2012 Jan-Feb;8(1):1-7
pubmed: 22030146
BMC Med Imaging. 2021 Apr 12;21(1):68
pubmed: 33845776
J Hepatol. 2018 Feb;68(2):268-279
pubmed: 29122391
J Pediatr (Rio J). 2017 Nov - Dec;93(6):551-559
pubmed: 28822233
Hepatology. 2019 Jun;69(6):2672-2682
pubmed: 30179269
Endocrinol Diabetes Metab. 2020 Sep 17;3(4):e00184
pubmed: 33102800
J Hepatol. 2016 Oct;65(4):784-790
pubmed: 27235307
Gastroenterology. 2009 Jan;136(1):160-7
pubmed: 18992746
Clin Res Hepatol Gastroenterol. 2021 Jul 24;46(1):101755
pubmed: 34311134
Hepatology. 2018 Oct;68(4):1376-1390
pubmed: 29665034
Hepatology. 2018 Oct;68(4):1319-1330
pubmed: 28926121
Am J Clin Nutr. 2008 Mar;87(3):534-8
pubmed: 18326589
BMC Med. 2009 May 01;7:21
pubmed: 19409076
Rev Cardiovasc Med. 2021 Sep 24;22(3):755-768
pubmed: 34565074
J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):319-334
pubmed: 28107283
Gastroenterology. 2020 May;158(7):1999-2014.e1
pubmed: 32044314
J Hepatol. 2016 Jun;64(6):1388-402
pubmed: 27062661
Transplantation. 2019 Jan;103(1):140-148
pubmed: 30451739
J Hepatol. 2021 Nov;75(5):1042-1048
pubmed: 34289397
Gut. 2010 Feb;59(2):267-73
pubmed: 20176643
Cell Mol Gastroenterol Hepatol. 2022;13(1):173-191
pubmed: 34411785
J Hepatol. 2017 Sep;67(3):568-576
pubmed: 28619255
J Pediatr Gastroenterol Nutr. 2015 Apr;60(4):550-61
pubmed: 25591123
Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):517-530
pubmed: 31278377
J Pediatr. 2017 Jan;180:31-37.e2
pubmed: 27697327
Semin Liver Dis. 2018 Feb;38(1):1-13
pubmed: 29471561
Nat Commun. 2019 Mar 29;10(1):1406
pubmed: 30926798
Clin Mol Hepatol. 2021 Apr;27(2):257-269
pubmed: 33751877
World J Gastroenterol. 2016 Sep 28;22(36):8078-93
pubmed: 27688650
Ann Hepatol. 2020 Jul - Aug;19(4):359-366
pubmed: 32349939
AJR Am J Roentgenol. 2021 Oct;217(4):996-1006
pubmed: 33438457
J Pediatr Gastroenterol Nutr. 2011 Aug;53(2):190-5
pubmed: 21788761
J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):443-50
pubmed: 18030211
Clin Liver Dis. 2016 May;20(2):325-38
pubmed: 27063272
Curr Diab Rep. 2014 Aug;14(8):508
pubmed: 24919749
Pilot Feasibility Stud. 2018 Jun 5;4:109
pubmed: 29992039
PLoS One. 2014 Aug 14;9(8):e104558
pubmed: 25121514
J Hepatol. 2021 Sep;75(3):659-689
pubmed: 34166721
Child Obes. 2017 Aug;13(4):272-282
pubmed: 28322576
World J Gastroenterol. 2016 Oct 21;22(39):8812-8819
pubmed: 27818597
J Clin Invest. 2017 Jun 30;127(7):2697-2704
pubmed: 28628033
Pediatrics. 2006 Oct;118(4):1388-93
pubmed: 17015527
J Ultrasound Med. 2017 Nov;36(11):2337-2344
pubmed: 28586157
J Intern Med. 2018 Apr;283(4):356-370
pubmed: 29280273
J Clin Med. 2021 Mar 01;10(5):
pubmed: 33804296
Gastroenterology. 2020 Oct;159(4):1290-1301.e5
pubmed: 32553765
Clin Exp Hepatol. 2019 Mar;5(1):11-21
pubmed: 30915402
Lancet. 2016 Feb 13;387(10019):679-690
pubmed: 26608256
Clin Liver Dis. 2016 May;20(2):293-312
pubmed: 27063270
PLoS One. 2015 Oct 29;10(10):e0140908
pubmed: 26512983
Nature. 2013 Aug 29;500(7464):541-6
pubmed: 23985870
Hepatology. 2012 Jun;55(6):2005-23
pubmed: 22488764
Can J Diabetes. 2019 Mar;43(2):136-145
pubmed: 30195966
Clin Gastroenterol Hepatol. 2021 Apr 14;:
pubmed: 33862225
Dig Liver Dis. 2021 Jun;53(6):746-752
pubmed: 33334704
Sci Rep. 2020 Sep 22;10(1):15424
pubmed: 32963289
J Hepatol. 2020 Sep;73(3):516-522
pubmed: 32531415
Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007340
pubmed: 20091629
Gastroenterology. 2016 May;150(5):1147-1159.e5
pubmed: 26874076
Gut. 2009 Nov;58(11):1538-44
pubmed: 19625277
J Pediatr Gastroenterol Nutr. 2013 Jul;57(1):119-23
pubmed: 23518484
Diabetes Care. 2020 Jun;43(6):1326-1335
pubmed: 32295809
Hepatology. 2007 Apr;45(4):846-54
pubmed: 17393509
Lancet. 2011 Aug 27;378(9793):804-14
pubmed: 21872749
BMC Pediatr. 2019 Apr 15;19(1):112
pubmed: 30987634
Diabetes Obes Metab. 2019 May;21(5):1237-1250
pubmed: 30697905
J Pediatr Gastroenterol Nutr. 2012 May;54(5):700-13
pubmed: 22395188
J Hepatol. 2019 Dec;71(6):1216-1228
pubmed: 31419514
Endocr Rev. 2018 Apr 1;39(2):79-132
pubmed: 29518206
J Dig Dis. 2021 Feb;22(2):72-82
pubmed: 33385317
Surg Obes Relat Dis. 2018 Jul;14(7):882-901
pubmed: 30077361
N Engl J Med. 2010 Sep 30;363(14):1341-50
pubmed: 20879883
Mayo Clin Proc. 2017 Feb;92(2):251-265
pubmed: 28065514
Hepatology. 2017 Nov;66(5):1373-1376
pubmed: 28741294
Pediatr Obes. 2019 Aug;14(8):e12522
pubmed: 30990572
Lancet. 2020 Jan 4;395(10217):65-74
pubmed: 31852602
World J Hepatol. 2015 Nov 8;7(25):2597-602
pubmed: 26557952