Efficacy and Synergy of Small Molecule Inhibitors Targeting

FMS-like tyrosine kinase 3 WS6 acute myeloid leukemia cabozantinib ispinesib ponatinib targeted therapy tyrosine kinase inhibitor

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
08 Dec 2021
Historique:
received: 27 08 2021
revised: 01 12 2021
accepted: 03 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

Constitutive activation of FLT3 by ITD mutations is one of the most common genetic aberrations in AML, present in ~1/3 of cases. Patients harboring

Identifiants

pubmed: 34944800
pii: cancers13246181
doi: 10.3390/cancers13246181
pmc: PMC8699584
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Austrian Science Fund FWF
ID : I 4157
Pays : Austria

Références

Lancet Oncol. 2017 Aug;18(8):1061-1075
pubmed: 28645776
Nat Commun. 2019 Nov 13;10(1):5140
pubmed: 31723137
Hematol Oncol Clin North Am. 2017 Aug;31(4):681-692
pubmed: 28673395
Oncogene. 2004 May 27;23(25):4454-65
pubmed: 15064750
Blood. 2002 Sep 1;100(5):1532-42
pubmed: 12176867
Clin Cancer Res. 2021 Jul 15;27(14):4003-4011
pubmed: 34103301
Lancet Oncol. 2018 Jul;19(7):889-903
pubmed: 29859851
PLoS One. 2013 Nov 13;8(11):e78556
pubmed: 24236021
Leukemia. 2019 Feb;33(2):299-312
pubmed: 30651634
Cancer Sci. 2020 Feb;111(2):312-322
pubmed: 31821677
Haematologica. 2021 Apr 01;106(4):1022-1033
pubmed: 33504139
Cancer Lett. 2016 Jul 1;376(2):218-25
pubmed: 27060207
Cells. 2020 Nov 17;9(11):
pubmed: 33212779
Cancers (Basel). 2019 Dec 03;11(12):
pubmed: 31817042
Stem Cell Investig. 2017 Jun 02;4:48
pubmed: 28607922
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Leukemia. 2015 Dec;29(12):2382-9
pubmed: 26172401
Blood. 2015 May 21;125(21):3236-45
pubmed: 25795921
Haematologica. 2011 Jan;96(1):62-8
pubmed: 20952518
Chem Biol Drug Des. 2011 Jan;77(1):1-11
pubmed: 21118377
Bioinformatics. 2017 Aug 1;33(15):2413-2415
pubmed: 28379339
Cancer Res. 2009 Apr 1;69(7):3032-41
pubmed: 19318574
Appl Health Econ Health Policy. 2013 Jun;11(3):275-86
pubmed: 23677706
Invest New Drugs. 2008 Jun;26(3):249-55
pubmed: 17962907
J Am Chem Soc. 2013 Feb 6;135(5):1669-72
pubmed: 23330637
Blood. 2018 Aug 9;132(6):598-607
pubmed: 29875101
Blood. 2007 Feb 15;109(4):1643-52
pubmed: 17047150
Nature. 2012 Apr 15;485(7397):260-3
pubmed: 22504184
Clin Cancer Res. 2010 Jan 15;16(2):566-76
pubmed: 20068098
Int J Mol Sci. 2019 Jul 12;20(14):
pubmed: 31336846
Blood. 2005 Jan 1;105(1):54-60
pubmed: 15345597
Nature. 1994 Apr 14;368(6472):643-8
pubmed: 8145851
Nature. 2018 Oct;562(7728):526-531
pubmed: 30333627
Curr Opin Struct Biol. 2016 Dec;41:145-150
pubmed: 27521655
Leukemia. 2021 Jul;35(7):2017-2029
pubmed: 33149267
N Engl J Med. 2015 Sep 17;373(12):1136-52
pubmed: 26376137
Nucleic Acids Res. 2019 Jul 2;47(W1):W357-W364
pubmed: 31106366
Curr Protoc Pharmacol. 2013 Mar;Chapter 2:Unit2.9
pubmed: 23456613
Recent Results Cancer Res. 2018;211:67-75
pubmed: 30069760
Haematologica. 2019 Oct;104(10):2017-2027
pubmed: 30923103
Haematologica. 2019 Oct;104(10):1907-1909
pubmed: 31575669
Leukemia. 2016 May;30(5):1025-32
pubmed: 26686245
Nucleic Acids Res. 2020 Jul 2;48(W1):W488-W493
pubmed: 32246720
Haematologica. 2017 Apr;102(4):e129-e131
pubmed: 28034991
Onco Targets Ther. 2019 Jan 18;12:635-645
pubmed: 30705592
Mol Cancer Ther. 2008 Oct;7(10):3176-86
pubmed: 18852121
Leukemia. 2018 May;32(5):1135-1146
pubmed: 29472718
Oncol Rev. 2012 Apr 17;6(1):e8
pubmed: 25992210
Crit Rev Oncol Hematol. 2019 Sep;141:125-138
pubmed: 31279288

Auteurs

Javier Bregante (J)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Anna Schönbichler (A)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Daniel Pölöske (D)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Lina Degenfeld-Schonburg (L)

Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.

Garazi Monzó Contreras (G)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Emir Hadzijusufovic (E)

Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Clinic for Companion Animals and Horses, University Clinic for Small Animals, Internal Medicine Small Animals, University of Veterinary Medicine, 1210 Vienna, Austria.

Elvin D de Araujo (ED)

Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, ON L5L1C6, Canada.
Centre for Medicinal Chemistry, University of Toronto Mississauga, Mississauga, ON L5L1C6, Canada.

Peter Valent (P)

Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.

Richard Moriggl (R)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Anna Orlova (A)

Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.

Classifications MeSH