Therapeutic Targets in Diffuse Midline Gliomas-An Emerging Landscape.
diffuse midline gliomas
molecular targets
potential therapy development
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Dec 2021
13 Dec 2021
Historique:
received:
19
10
2021
revised:
07
12
2021
accepted:
08
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Diffuse midline gliomas (DMGs) are invariably fatal pediatric brain tumours that are inherently resistant to conventional therapy. In recent years our understanding of the underlying molecular mechanisms of DMG tumorigenicity has resulted in the identification of novel targets and the development of a range of potential therapies, with multiple agents now being progressed to clinical translation to test their therapeutic efficacy. Here, we provide an overview of the current therapies aimed at epigenetic and mutational drivers, cellular pathway aberrations and tumor microenvironment mechanisms in DMGs in order to aid therapy development and facilitate a holistic approach to patient treatment.
Identifiants
pubmed: 34944870
pii: cancers13246251
doi: 10.3390/cancers13246251
pmc: PMC8699135
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Cancer Australia
ID : RG190165
Organisme : Cancer Institute of New South Wales
ID : TPG2037
Organisme : DIPG collaborative
ID : N/A
Organisme : The Cure Starts Now
ID : N/A
Organisme : Kids Cancer Project
ID : N/A
Organisme : Isaac McKinnes Fund
ID : N/A
Organisme : Levi's Project
ID : N/A
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