Expression of Endogenous Retroviral RNA in Prostate Tumors has Prognostic Value and Shows Differences among Americans of African Versus European/Middle Eastern Ancestry.
ancestral differences
cancer prognostics
genetic variation
human endogenous retrovirus
prostate cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
23
11
2021
revised:
10
12
2021
accepted:
15
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Endogenous retroviruses (ERVs) are abundant, repetitive elements dispersed across the human genome and are implicated in various diseases. We investigated two potential roles for ERVs in prostate cancer (PCa). First, the PCa of Black Americans (BA) is diagnosed at an earlier median age and at a more advanced stage than the PCa of White Americans (WA). We used publicly available RNA-seq data from tumor-enriched samples of 27 BA and 65 WA PCa patients in order to identify 12 differentially expressed ERVs (
Identifiants
pubmed: 34944967
pii: cancers13246347
doi: 10.3390/cancers13246347
pmc: PMC8699453
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : NCI-CA125123
Pays : United States
Organisme : American Cancer Society
ID : IRG-16-187-13
Organisme : NIH HHS
ID : R01CA226570
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA226570
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA062203
Pays : United States
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