Cobaltabis(dicarbollide) ([
3D cell models
C. elegans
COSAN
boron clusters
boron neutron capture therapy (BNCT)
glioblastoma
in vitro BNCT effect
metallacarboranes
small molecules
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
19 Dec 2021
19 Dec 2021
Historique:
received:
29
10
2021
revised:
10
12
2021
accepted:
16
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The aim of our study was to assess if the sodium salt of cobaltabis(dicarbollide) and its di-iodinated derivative (Na[ The biological activities of the small molecules were evaluated in vitro with glioblastoma cells lines U87 and T98G in 2D and 3D cell models and in vivo in the small model animal Our studies indicated that only spheroids from the U87 cell line have impaired growth after treatment with both compounds, suggesting an increased resistance from T98G spheroids, contrary to what was observed in the monolayer culture, which highlights the need to employ 3D models for future GBM studies. In vitro tests in U87 and T98G cells conclude that the amount of These small molecules, particularly [8,8'-I
Identifiants
pubmed: 34944987
pii: cancers13246367
doi: 10.3390/cancers13246367
pmc: PMC8699431
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Spanish Ministerio de Economía y Competitividad
ID : PID2019-106832RB-I00
Organisme : Spanish Ministerio de Economía y Competitividad
ID : RTI2018-096273-B-I00
Organisme : Government of Catalonia
ID : 2017SGR1720
Organisme : Government of Catalonia
ID : 2017SGR765
Organisme : Severo Ochoa Programme for Centres of Excellence in R&D
ID : SEV-2015-0496
Organisme : Italian Association for Cancer Research
ID : IG 2019 - ID. 23267
Organisme : Fundação para a Ciência e Tecnologia
ID : UID/MULTI/04349/2019
Organisme : Fundação para a Ciência e Tecnologia
ID : PTDC/BTM-TEC/29256/2017
Références
Microsyst Nanoeng. 2020 May 4;6:29
pubmed: 32382445
Nanotoxicology. 2017 Jun;11(5):647-657
pubmed: 28673184
J Chem Inf Model. 2007 Jul-Aug;47(4):1395-404
pubmed: 17569522
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Genes Dis. 2016 May 11;3(3):198-210
pubmed: 30258889
Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14113-7
pubmed: 26425966
Appl Radiat Isot. 2014 Jun;88:16-9
pubmed: 24373823
J Neurooncol. 1997 May;33(1-2):117-30
pubmed: 9151229
Cell Rep. 2017 Nov 21;21(8):2183-2197
pubmed: 29166609
Front Mol Biosci. 2020 Dec 01;7:609172
pubmed: 33335914
Chem. 2018 Jan 11;4(1):46-93
pubmed: 29629424
Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12114-8
pubmed: 24307454
Langmuir. 2006 Jan 17;22(2):575-81
pubmed: 16401104
Front Oncol. 2017 Dec 11;7:293
pubmed: 29322028
Angew Chem Int Ed Engl. 2011 Dec 23;50(52):12491-5
pubmed: 22052578
Life (Basel). 2021 Apr 10;11(4):
pubmed: 33920126
ChemMedChem. 2019 Apr 17;14(8):823-832
pubmed: 30707500
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15394-9
pubmed: 16227435
J Am Chem Soc. 2020 May 20;142(20):9396-9407
pubmed: 32323984
Chem Soc Rev. 2016 Oct 7;45(19):5147-73
pubmed: 27188393
Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11716-54
pubmed: 25204549
Sci Rep. 2017 Aug 29;7(1):9800
pubmed: 28852112
Acta Biomater. 2017 Apr 15;53:598-609
pubmed: 28161575
Chem Sci. 2016 Sep 1;7(9):5786-5797
pubmed: 30034717
Chem Commun (Camb). 2020 Aug 14;56(63):8972-8975
pubmed: 32638718
JAMA Oncol. 2015 Jul;1(4):505-27
pubmed: 26181261
Angew Chem Int Ed Engl. 2011 May 27;50(23):5298-300
pubmed: 21563280
Br J Radiol. 2010 Jul;83(991):596-603
pubmed: 20603410
J Phys Chem A. 2015 Jan 8;119(1):183-94
pubmed: 25495236
Dalton Trans. 2014 Apr 7;43(13):5062-8
pubmed: 24336935
Chemistry. 2014 May 26;20(22):6786-94
pubmed: 24737689
Chem Commun (Camb). 2014 Jun 28;50(51):6700-3
pubmed: 24695803
Iran J Med Sci. 2017 May;42(3):258-265
pubmed: 28533574
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
Chem Commun (Camb). 2009 Sep 7;(33):4988-90
pubmed: 19668825
Curr Med Chem. 2021;28(2):266-283
pubmed: 31965939
Chemistry. 2019 Oct 1;25(55):12820-12829
pubmed: 31411775
Chemistry. 2018 Nov 22;24(65):17239-17254
pubmed: 30222214
Chem Commun (Camb). 2014 Oct 7;50(77):11415-7
pubmed: 25130941
Cancer Res. 2011 Mar 15;71(6):2308-17
pubmed: 21406402
Sci Rep. 2015 Jan 15;5:7804
pubmed: 25588708
Trends Pharmacol Sci. 2009 Aug;30(8):431-40
pubmed: 19616318
Med Radiol (Mosk). 1981 Jun;26(6):62-4
pubmed: 7266291
Chemphyschem. 2012 Apr 23;13(6):1421-4
pubmed: 22407787
Cancer Commun (Lond). 2018 Jun 19;38(1):37
pubmed: 29914577
Chem Commun (Camb). 2008 Dec 28;(48):6492-4
pubmed: 19057756
Neurol Res Int. 2012;2012:878425
pubmed: 22530127
Cancer Commun (Lond). 2020 Sep;40(9):406-421
pubmed: 32805063
Cancer Commun (Lond). 2018 Jun 19;38(1):36
pubmed: 29914575
Chem Rev. 2015 Aug 12;115(15):8038-155
pubmed: 25996028
Radiat Oncol. 2017 Jan 23;12(1):26
pubmed: 28114947
J Clin Diagn Res. 2016 Dec;10(12):ZE01-ZE04
pubmed: 28209015
Langmuir. 2016 Jul 5;32(26):6713-22
pubmed: 27287067
Chem Commun (Camb). 2014 Mar 28;50(25):3370-2
pubmed: 24549036
Adv Drug Deliv Rev. 2002 Mar 31;54(3):355-66
pubmed: 11922952
Radiat Med. 2006 Feb;24(2):98-107
pubmed: 16715670
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Int J Mol Sci. 2021 Sep 14;22(18):
pubmed: 34576098
J Phys Chem B. 2006 May 18;110(19):9488-98
pubmed: 16686495