Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry.

cardiovascular disease hospital admissions infections mortality neoplasm systemic lupus erythematosus

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
08 Dec 2021
Historique:
received: 22 11 2021
revised: 03 12 2021
accepted: 06 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

the admission and death causes of SLE patients might have changed over the last years. Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997-2000, 2001-2005, 2006-2010, and 2011-2015). The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997-2000 to 31,977 in 2011-2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality.

Sections du résumé

BACKGROUND BACKGROUND
the admission and death causes of SLE patients might have changed over the last years.
METHODS METHODS
Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997-2000, 2001-2005, 2006-2010, and 2011-2015).
RESULTS RESULTS
The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997-2000 to 31,977 in 2011-2015. SLE decreased as a cause of admission (from 47.1% to 20.8%,
CONCLUSIONS CONCLUSIONS
Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality.

Identifiants

pubmed: 34945045
pii: jcm10245749
doi: 10.3390/jcm10245749
pmc: PMC8707218
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III
ID : CM19/00223

Références

Science. 2011 Mar 25;331(6024):1565-70
pubmed: 21436444
Autoimmun Rev. 2004 Aug;3(6):423-53
pubmed: 15351310
Rheumatol Int. 2013 Jun;33(6):1541-6
pubmed: 23263494
Ann Intern Med. 2017 Dec 5;167(11):777-785
pubmed: 29086801
Rheumatol Int. 2018 Oct;38(10):1841-1846
pubmed: 30151719
Lupus. 2018 Feb;27(2):336-342
pubmed: 29173007
J Autoimmun. 2013 May;42:130-5
pubmed: 23410586
J Rheumatol. 2008 Nov;35(11):2152-8
pubmed: 18793004
Toxicology. 2003 Apr 1;185(3):229-40
pubmed: 12581698
Lupus. 2018 Sep;27(10):1577-1581
pubmed: 30016928
Curr Opin Rheumatol. 2018 Sep;30(5):482-489
pubmed: 29870497
PLoS One. 2015 Jun 18;10(6):e0128920
pubmed: 26087254
Nat Rev Rheumatol. 2011 May 31;7(7):399-408
pubmed: 21629241
Curr Opin Rheumatol. 2019 Nov;31(6):678-681
pubmed: 31403485
Lancet. 2014 Nov 22;384(9957):1878-1888
pubmed: 24881804
Lupus. 2021 Apr;30(5):702-706
pubmed: 33472522
Arthritis Care Res (Hoboken). 2018 Apr;70(4):582-591
pubmed: 28704598
Medicine (Baltimore). 2003 Sep;82(5):299-308
pubmed: 14530779
Medicine (Baltimore). 2011 Sep;90(5):350-358
pubmed: 21857367
Rheumatology (Oxford). 2013 May;52(5):905-9
pubmed: 23307831
Lupus. 2016 Jan;25(1):28-37
pubmed: 26199283
Arthritis Rheum. 2006 Aug;54(8):2550-7
pubmed: 16868977
Ann Rheum Dis. 2019 Jun;78(6):736-745
pubmed: 30926722
Arthritis Care Res (Hoboken). 2012 Feb;64(2):159-68
pubmed: 22052624
Lupus Sci Med. 2018 Jun 4;5(1):e000249
pubmed: 29955368
Nat Rev Dis Primers. 2016 Jun 16;2:16039
pubmed: 27306639
Lupus. 2019 Oct;28(12):1488-1494
pubmed: 31551031
Lupus. 2013 Oct;22(12):1286-94
pubmed: 24098001
Lupus. 2016 Jun;25(7):727-34
pubmed: 26811368
Rheumatol Int. 2019 Dec;39(12):2069-2075
pubmed: 31570977
Curr Rheumatol Rep. 2016 Apr;18(4):21
pubmed: 26984805
Med Sci Monit. 2019 Oct 27;25:8061-8068
pubmed: 31655846
Arthritis Rheumatol. 2021 Apr;73(4):617-630
pubmed: 33142044
J Rheumatol. 2017 Aug;44(8):1173-1178
pubmed: 28620060
Arthritis Care Res (Hoboken). 2014 Apr;66(4):608-16
pubmed: 24106157
Arthritis Rheumatol. 2018 Aug;70(8):1251-1255
pubmed: 29671279
Clin Rheumatol. 2014 Jan;33(1):57-63
pubmed: 24046218
Lupus. 2020 Mar;29(3):344-350
pubmed: 32046576
Rheumatology (Oxford). 2020 Dec 5;59(Suppl5):v29-v38
pubmed: 33280012
Ann Rheum Dis. 2016 Jan;75(1):136-41
pubmed: 25265938
Arthritis Care Res (Hoboken). 2021 Oct;73(10):1444-1450
pubmed: 32558160
J Rheumatol. 2006 Sep;33(9):1770-4
pubmed: 16832848
Lupus. 2018 Jan;27(1):165-171
pubmed: 29050537
Lupus. 2019 Aug;28(9):1158-1166
pubmed: 31299879
J Rheumatol. 2007 Jan;34(1):70-5
pubmed: 17117488
Ann Rheum Dis. 2019 Jun;78(6):802-806
pubmed: 30992296

Auteurs

Víctor Moreno-Torres (V)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Carlos Tarín (C)

Basic Medical Sciences, Faculty of Medicine, Universidad CEU San Pablo, 28003 Madrid, Spain.

Guillermo Ruiz-Irastorza (G)

Autoimmune Diseases Research Unit, BioCruces Bizkaia Health Research Institute, UPV/EHU, 48903 Bizkaia, Spain.

Raquel Castejón (R)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Ángela Gutiérrez-Rojas (Á)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Ana Royuela (A)

Clinical Biostatistics Unit, Health Research Institute Puerta de Hierro-Segovia de Arana, CIBERESP, 28222 Madrid, Spain.

Pedro Durán-Del Campo (P)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Susana Mellor-Pita (S)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Pablo Tutor (P)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Silvia Rosado (S)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Enrique Sánchez (E)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

María Martínez-Urbistondo (M)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Carmen de Mendoza (C)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Miguel Yebra (M)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Juan-Antonio Vargas (JA)

Internal Medicine Department, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHIM), Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain.

Classifications MeSH