Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study.

COVID-19 FIASMA SARS-CoV-2 death hydroxyzine inpatients mortality treatment

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
15 Dec 2021
Historique:
received: 17 11 2021
revised: 10 12 2021
accepted: 11 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

(1) Background: Based on its antiviral activity, anti-inflammatory properties, and functional inhibition effects on the acid sphingomyelinase/ceramide system (FIASMA), we sought to examine the potential usefulness of the H1 antihistamine hydroxyzine in patients hospitalized for COVID-19. (2) Methods: In a multicenter observational study, we included 15,103 adults hospitalized for COVID-19, of which 164 (1.1%) received hydroxyzine within the first 48 h of hospitalization, administered orally at a median daily dose of 25.0 mg (SD = 29.5). We compared mortality rates between patients who received hydroxyzine at hospital admission and those who did not, using a multivariable logistic regression model adjusting for patients' characteristics, medical conditions, and use of other medications. (3) Results: This analysis showed a significant association between hydroxyzine use and reduced mortality (AOR, 0.51; 95%CI, 0.29-0.88,

Identifiants

DOI: 10.3390/jcm10245891 PMID: 34945186 PMC: PMC8707307
pubmed: 34945186
pii: jcm10245891
doi: 10.3390/jcm10245891
pmc: PMC8707307
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Open Forum Infect Dis. 2021 Feb 01;8(2):ofab050
pubmed: 33623808
J Med Virol. 2020 Oct;92(10):1733-1734
pubmed: 32242950
Cell Physiol Biochem. 2010;26(1):9-20
pubmed: 20502000
Allergy Asthma Proc. 2007 Jan-Feb;28(1):10-5
pubmed: 17390750
Lancet Infect Dis. 2020 Apr;20(4):400-402
pubmed: 32113509
Br J Clin Pharmacol. 2021 Oct;87(10):3766-3775
pubmed: 33608891
Encephale. 2020 Jun;46(3):193-201
pubmed: 32370982
Front Pharmacol. 2020 Nov 09;11:582310
pubmed: 33364957
JAMA. 2020 Dec 8;324(22):2292-2300
pubmed: 33180097
JAMA Intern Med. 2022 Jan 1;182(1):19-25
pubmed: 34747982
Front Pharmacol. 2020 Nov 20;11:584881
pubmed: 33692684
J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670
pubmed: 32196083
PLoS One. 2021 Feb 19;16(2):e0247122
pubmed: 33606790
Biomed Pharmacother. 2020 Oct;130:110582
pubmed: 32763818
Eur J Pharmacol. 2021 Apr 5;896:173897
pubmed: 33497607
Clin Drug Investig. 2021 Mar;41(3):221-233
pubmed: 33559821
Int Arch Allergy Immunol. 2010;151(1):56-69
pubmed: 19672097
Pharmacoepidemiol Drug Saf. 2006 May;15(5):291-303
pubmed: 16447304
PLoS One. 2011;6(8):e23852
pubmed: 21909365
Cell Rep Med. 2020 Nov 17;1(8):100142
pubmed: 33163980
Biochem Biophys Res Commun. 2021 Jan 29;538:173-179
pubmed: 33309272
Nat Med. 2020 Sep;26(9):1417-1421
pubmed: 32665655
J Biol Chem. 2021 Jan-Jun;296:100701
pubmed: 33895135
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
Biochem Med (Zagreb). 2021 Feb 15;31(1):010502
pubmed: 33380887
Pharmaceuticals (Basel). 2021 Mar 07;14(3):
pubmed: 33799977
Mol Psychiatry. 2021 Dec;26(12):7098-7099
pubmed: 34385600
Ann Intern Med. 2007 Oct 16;147(8):573-7
pubmed: 17938396
Emerg Microbes Infect. 2020 Dec;9(1):2245-2255
pubmed: 32975484
Front Pharmacol. 2021 Apr 20;12:652688
pubmed: 33959018
Sci Transl Med. 2019 Feb 6;11(478):
pubmed: 30728287
Int J Mol Sci. 2021 Apr 30;22(9):
pubmed: 33946479
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
JAMA Netw Open. 2021 Nov 1;4(11):e2136510
pubmed: 34779851
Mol Psychiatry. 2021 Sep;26(9):5199-5212
pubmed: 33536545
Clin Pharmacol Ther. 2021 Dec;110(6):1498-1511
pubmed: 34050932
Sci Rep. 2021 Nov 4;11(1):21633
pubmed: 34737330
Adv Appl Bioinform Chem. 2021 Apr 12;14:71-85
pubmed: 33880039
J Travel Med. 2021 Feb 23;28(2):
pubmed: 33506243
Drug Discov Today. 2020 Aug;25(8):1287-1290
pubmed: 32593662
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Int J Mol Sci. 2021 Sep 22;22(19):
pubmed: 34638539
Lancet Glob Health. 2022 Jan;10(1):e42-e51
pubmed: 34717820
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859

Auteurs

Marina Sánchez-Rico (M)

Département de Psychiatrie, Hôpital Corentin-Celton, AP-HP.Centre-Université de Paris, 92130 Issy-les-Moulineaux, France.
Department of Psychobiology & Behavioural Sciences Methods, Faculty of Psychology, Campus de Somosaguas Universidad Complutense de Madrid, 28223 Pozuelo de Alarcon, Spain.
ORCID: 0000-0002-1121-8641

Frédéric Limosin (F)

Département de Psychiatrie, Hôpital Corentin-Celton, AP-HP.Centre-Université de Paris, 92130 Issy-les-Moulineaux, France.
Institut de Psychiatrie et Neurosciences de Paris, Université de Paris, UMR_S1266, INSERM, 75014 Paris, France.
UFR de Médecine, Faculté de Santé, Université de Paris, 75006 Paris, France.

Raphaël Vernet (R)

Hôpital Européen Georges Pompidou, Medical Informatics, Biostatistics and Public Health Department, AP-HP.Centre-Université de Paris, 75015 Paris, France.

Nathanaël Beeker (N)

Unité de Recherche Clinique, Hopital Cochin, Assistance Publique-Hopitaux de Paris, 75004 Paris, France.

Antoine Neuraz (A)

Cordeliers Research Center, Université de Paris, UMRS 1138, INSERM, 75006 Paris, France.
Department of Medical Informatics, Necker-Enfants Malades Hospital, AP-HP, Centre-Université de Paris, 75015 Paris, France.

Carlos Blanco (C)

Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD 20852, USA.

Mark Olfson (M)

Department of Psychiatry, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA.

Cédric Lemogne (C)

Département de Psychiatrie, Hôpital Corentin-Celton, AP-HP.Centre-Université de Paris, 92130 Issy-les-Moulineaux, France.
Institut de Psychiatrie et Neurosciences de Paris, Université de Paris, UMR_S1266, INSERM, 75014 Paris, France.
UFR de Médecine, Faculté de Santé, Université de Paris, 75006 Paris, France.
ORCID: 0000-0002-3487-4721

Pierre Meneton (P)

Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé, UMR 1142, INSERM, Sorbonne Université, Université Paris 13, 93017 Paris, France.
ORCID: 0000-0003-4611-1892

Christel Daniel (C)

AP-HP, DSI-WIND (Web Innovation Données), 75184 Paris, France.
Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé, Sorbonne University, University Paris 13, Sorbonne Paris Cité, INSERM UMRS 1142, 75012 Paris, France.

Nicolas Paris (N)

AP-HP, DSI-WIND (Web Innovation Données), 75184 Paris, France.
LIMSI, CNRS, Université Paris-Sud, Université Paris-Saclay, 91405 Orsay, France.

Alexandre Gramfort (A)

Institut National de Recherche en Sciences et Technologies du Numérique (INRIA), Université Paris-Saclay, INRIA, CEA, 75012 Palaiseau, France.

Guillaume Lemaitre (G)

Institut National de Recherche en Sciences et Technologies du Numérique (INRIA), Université Paris-Saclay, INRIA, CEA, 75012 Palaiseau, France.

Pedro De La Muela (P)

Département de Psychiatrie, Hôpital Corentin-Celton, AP-HP.Centre-Université de Paris, 92130 Issy-les-Moulineaux, France.
Department of Psychobiology & Behavioural Sciences Methods, Faculty of Psychology, Campus de Somosaguas Universidad Complutense de Madrid, 28223 Pozuelo de Alarcon, Spain.

Elisa Salamanca (E)

Banque Nationale de Données Maladies Rares (BNDMR), Campus Picpus, Département WIND (Web Innovation Données), AP-HP, 75012 Paris, France.

Mélodie Bernaux (M)

Direction de la Stratégie et de la Transformation, AP-HP, 75004 Paris, France.

Ali Bellamine (A)

Unité de Recherche Clinique, Hôpital Cochin, AP-HP, Centre-Université de Paris, 75014 Paris, France.

Anita Burgun (A)

Cordeliers Research Center, Université de Paris, UMRS 1138, INSERM, 75006 Paris, France.

Nicolas Hoertel (N)

Département de Psychiatrie, Hôpital Corentin-Celton, AP-HP.Centre-Université de Paris, 92130 Issy-les-Moulineaux, France.
Institut de Psychiatrie et Neurosciences de Paris, Université de Paris, UMR_S1266, INSERM, 75014 Paris, France.
UFR de Médecine, Faculté de Santé, Université de Paris, 75006 Paris, France.
ORCID: 0000-0002-7890-1349

Classifications MeSH