Uveitis and Other Ocular Complications Following COVID-19 Vaccination.

COVID-19 SARS-CoV-2 disease ocular complications uveitis vaccination vaccine vaccine-associated uveitis

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
19 Dec 2021
Historique:
received: 19 11 2021
revised: 07 12 2021
accepted: 17 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

Coronavirus disease 2019 (COVID-19) vaccines can cause transient local and systemic post-vaccination reactions. The aim of this study was to report uveitis and other ocular complications following COVID-19 vaccination. The study included 42 eyes of 34 patients (20 females, 14 males), with a mean age of 49.8 years (range 18-83 years). The cases reported were three herpetic keratitis, two anterior scleritis, five anterior uveitis (AU), three toxoplasma retinochoroiditis, two Vogt-Koyanagi-Harada (VKH) disease reactivations, two pars planitis, two retinal vasculitis, one bilateral panuveitis in new-onset Behçet's disease, three multiple evanescent white dot syndromes (MEWDS), one acute macular neuroretinopathy (AMN), five retinal vein occlusions (RVO), one non-arteritic ischemic optic neuropathy (NAION), three activations of quiescent choroidal neovascularization (CNV) secondary to myopia or uveitis, and one central serous chorioretinopathy (CSCR). Mean time between vaccination and ocular complication onset was 9.4 days (range 1-30 days). Twenty-three cases occurred after Pfizer-BioNTech vaccination (BNT162b2 mRNA), 7 after Oxford-AstraZeneca vaccine (ChAdOx1 nCoV-19), 3 after ModernaTX vaccination (mRNA-1273), and 1 after Janssen Johnson & Johnson vaccine (Ad26.COV2). Uveitis and other ocular complications may develop after the administration of COVID-19 vaccine.

Identifiants

pubmed: 34945256
pii: jcm10245960
doi: 10.3390/jcm10245960
pmc: PMC8704915
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Elena Bolletta (E)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Danilo Iannetta (D)

Ophthalmology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Valentina Mastrofilippo (V)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Luca De Simone (L)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Fabrizio Gozzi (F)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Stefania Croci (S)

Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Martina Bonacini (M)

Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Lucia Belloni (L)

Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Alessandro Zerbini (A)

Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Chantal Adani (C)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.

Luigi Fontana (L)

Ophthalmology Unit, DIMES, Alma Mater Studiorum, University of Bologna, S. Orsola-Malpighi Teaching Hospital, 40138 Bologna, Italy.

Carlo Salvarani (C)

Rheumatology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.
Department of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Luca Cimino (L)

Ocular Immunology Unit, Azienda USL-IRCCS, 42123 Reggio Emilia, Italy.
Department of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Classifications MeSH