Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia.
BrainAGE
SNP
genetic variations
haplotypes
intron
ionotropic glutamate receptor
schizophrenia
scoring model
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
31
08
2021
revised:
14
11
2021
accepted:
16
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The heritable component of schizophrenia (SCH) as a polygenic trait is represented by numerous variants from a heterogeneous group of genes each contributing a relatively small effect. Various SNPs have already been found and analyzed in genes encoding the NMDAR subunits. However, less is known about genetic variations of genes encoding the AMPA and kainate receptor subunits. We analyzed sixteen iGluR genes in full length to determine the sequence variability of iGluR genes. Our aim was to describe the rate of genetic variability, its distribution, and the co-occurrence of variants and to identify new candidate risk variants or haplotypes. The cumulative effect of genetic risk was then estimated using a simple scoring model.
Identifiants
pubmed: 34945722
pii: jpm11121250
doi: 10.3390/jpm11121250
pmc: PMC8708351
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : LTAUSA19122
Organisme : Grantová Agentura České Republiky
ID : 20-179458
Organisme : Technologická Agentura České Republiky
ID : TN01000013
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : CZ.02.1.01/0.0/0.0/16_025/0007444
Organisme : Grantová Agentura, Univerzita Karlova
ID : 1206218
Organisme : Agentura Pro Zdravotnický Výzkum České Republiky
ID : NU21-04-00405
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