MicroRNA-Target Interaction Regulatory Network in Alzheimer's Disease.

Alzheimer’s disease biomarker miRNA–target interaction (MTI) microRNA (miRNA) protein–protein interaction (PPI)

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
02 Dec 2021
Historique:
received: 30 09 2021
revised: 20 11 2021
accepted: 26 11 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 25 12 2021
Statut: epublish

Résumé

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia; however, early diagnosis of the disease is challenging. Research suggests that biomarkers found in blood, such as microRNAs (miRNA), may be promising for AD diagnostics. Experimental data on miRNA-target interactions (MTI) associated with AD are scattered across databases and publications, thus making the identification of promising miRNA biomarkers for AD difficult. In response to this, a list of experimentally validated AD-associated MTIs was obtained from miRTarBase. Cytoscape was used to create a visual MTI network. STRING software was used for protein-protein interaction analysis and mirPath was used for pathway enrichment analysis. Several targets regulated by multiple miRNAs were identified, including:

Identifiants

pubmed: 34945753
pii: jpm11121275
doi: 10.3390/jpm11121275
pmc: PMC8708198
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Slovenian Research Agency
ID : P4-0220

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Auteurs

Aleksander Turk (A)

Department of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domžale, Slovenia.

Tanja Kunej (T)

Department of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domžale, Slovenia.

Borut Peterlin (B)

Clinical Institute of Genomic Medicine, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

Classifications MeSH