Towards Personalized Therapy of Aortic Stenosis.
advanced glycation end products
calcific aortic stenosis
calcification
inflammation
lipid lowering therapy
non-vitamin K antagonist oral anticoagulants
tissue inhibitors of matrix metalloproteinases
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
03 Dec 2021
03 Dec 2021
Historique:
received:
25
10
2021
revised:
23
11
2021
accepted:
29
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Calcific aortic stenosis (CAS) is the most common cause of acquired valvular heart disease in adults with no available pharmacological treatment to inhibit the disease progression to date. This review provides an up-to-date overview of current knowledge of molecular mechanisms underlying CAS pathobiology and the related treatment pathways. Particular attention is paid to current randomized trials investigating medical treatment of CAS, including strategies based on lipid-lowering and antihypertensive therapies, phosphate and calcium metabolism, and novel therapeutic targets such as valvular oxidative stress, coagulation proteins, matrix metalloproteinases, and accumulation of advanced glycation end products.
Identifiants
pubmed: 34945764
pii: jpm11121292
doi: 10.3390/jpm11121292
pmc: PMC8708539
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Science Center
ID : UMO-2018/29/B/NZ5/02629
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