Emerging Therapeutic Agents for Colorectal Cancer.
CRC
anticancer agents
cancer
emerging targets
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Dec 2021
09 Dec 2021
Historique:
received:
05
11
2021
revised:
03
12
2021
accepted:
06
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
12
2
2022
Statut:
epublish
Résumé
There are promising new therapeutic agents for CRC patients, including novel small-molecule inhibitors and immune checkpoint blockers. We focused on emerging CRC's therapeutic agents that have shown the potential for progress in clinical practice. This review provides an overview of tyrosine kinase inhibitors targeting VEGF and KIT, BRAF and MEK inhibitors, TLR9 agonist, STAT3 inhibitors, and immune checkpoint blockers (PD1/PDL-1 inhibitors), for which recent advances have been reported. These new agents have the potential to provide benefits to CRC patients with unmet medical needs.
Identifiants
pubmed: 34946546
pii: molecules26247463
doi: 10.3390/molecules26247463
pmc: PMC8707340
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Protein Kinase Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Association for Cancer Research
ID : IG2020 24703
Organisme : Sapienza University of Rome
ID : RP11715C7D1CF0D1
Organisme : Sapienza University of Rome
ID : RM11916B5598E3C4
Organisme : Sapienza University of Rome
ID : RP11715C34AEAC9B
Organisme : Institute Pasteur Italy
ID : Call 2019 aged under 45
Références
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
J Clin Invest. 2011 Nov;121(11):4311-21
pubmed: 21985784
Oncologist. 2019 Jul;24(7):883-e407
pubmed: 30877190
Biomedicines. 2020 Dec 17;8(12):
pubmed: 33348704
Cancers (Basel). 2020 Mar 31;12(4):
pubmed: 32244546
Pharmacol Rev. 2001 Jun;53(2):245-82
pubmed: 11356985
J Cancer. 2019 Jun 2;10(14):3112-3123
pubmed: 31289581
BMC Immunol. 2015 Jan 31;16:1
pubmed: 25636521
EMBO J. 2011 Jun 24;30(15):3186-99
pubmed: 21701559
Dig Dis Sci. 1998 Jan;43(1):8-14
pubmed: 9508539
Br J Pharmacol. 2013 Apr;168(7):1687-706
pubmed: 23126373
Mol Ther. 2017 May 3;25(5):1248-1258
pubmed: 28366766
J Exp Clin Cancer Res. 2019 Jun 4;38(1):236
pubmed: 31164152
Cell Stem Cell. 2014 Mar 6;14(3):306-21
pubmed: 24607405
J Cancer. 2020 Jan 1;11(3):750-758
pubmed: 31942198
Clin Cancer Res. 2008 Dec 15;14(24):8221-7
pubmed: 19088039
EMBO J. 2011 Mar 2;30(5):800-13
pubmed: 21297581
Cell Physiol Biochem. 2018;47(2):680-693
pubmed: 29794421
Front Oncol. 2021 Sep 23;11:730824
pubmed: 34631558
Eur Respir J. 2019 Sep 19;54(3):
pubmed: 31285305
Cancer Immunol Immunother. 1996 Dec;43(4):245-53
pubmed: 9003471
Oncol Res. 2019 Jul 12;27(7):835-847
pubmed: 30982499
Expert Opin Investig Drugs. 2017 Nov;26(11):1295-1305
pubmed: 28965421
Crit Rev Clin Lab Sci. 2002 Nov;39(6):527-79
pubmed: 12484499
Cancers (Basel). 2019 Dec 23;12(1):
pubmed: 31878090
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63
pubmed: 17548814
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
J Natl Cancer Inst. 2010 Dec 1;102(23):1760-70
pubmed: 21068432
Cancer Res. 2013 Jan 15;73(2):539-49
pubmed: 23108136
Daru. 2020 Jun;28(1):159-169
pubmed: 31942696
JAMA. 2008 Dec 17;300(23):2765-78
pubmed: 19088354
Int Immunopharmacol. 2020 Nov;88:106858
pubmed: 32795895
Biochem Biophys Res Commun. 2017 Jun 24;488(2):247-252
pubmed: 28373071
Cancer Prev Res (Phila). 2013 Jan;6(1):18-26
pubmed: 23248097
Development. 2014 Sep;141(18):3505-16
pubmed: 25183869
Expert Rev Anticancer Ther. 2021 Sep;21(9):917-926
pubmed: 34142932
Br J Haematol. 2007 Jul;138(1):12-30
pubmed: 17555444
Nucleic Acids Res. 1988 Aug 25;16(16):7773-82
pubmed: 3047672
Nat Immunol. 2004 Dec;5(12):1219-26
pubmed: 15549123
Nat Rev Drug Discov. 2017 Aug;16(8):525-526
pubmed: 28529321
Cancers (Basel). 2016 Jun 27;8(7):
pubmed: 27355964
Mol Cancer Ther. 2016 Jul;15(7):1580-90
pubmed: 27207778
Int J Oncol. 2019 Mar;54(3):1010-1020
pubmed: 30569106
Clin Infect Dis. 2017 Jun 15;64(12):1686-1695
pubmed: 28329286
Nat Rev Drug Discov. 2021 Dec;20(12):941-960
pubmed: 34616030
J Thorac Oncol. 2008 Feb;3(2):111-6
pubmed: 18303429
Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):357-68
pubmed: 12220549
Cancer Commun (Lond). 2018 Nov 1;38(1):66
pubmed: 30382933
Acta Ophthalmol. 2019 Dec 20;:
pubmed: 31863550
Lancet. 2013 Jan 26;381(9863):303-12
pubmed: 23177514
Dev Dyn. 2011 Sep;240(9):2166-74
pubmed: 22016184
Cancer Discov. 2016 Dec;6(12):1352-1365
pubmed: 27729313
World J Gastroenterol. 2014 Jul 21;20(27):8910-20
pubmed: 25083063
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Lab Invest. 2017 Oct;97(10):1142-1151
pubmed: 28394318
Oncotarget. 2017 Dec 22;9(70):33403-33415
pubmed: 30279970
Clin Colorectal Cancer. 2021 Mar;20(1):84-95.e8
pubmed: 33041226
Front Immunol. 2015 Oct 07;6:516
pubmed: 26500653
BMC Cancer. 2020 Jul 22;20(1):683
pubmed: 32698790
Drug Des Devel Ther. 2017 Sep 21;11:2801-2811
pubmed: 29033542
Annu Rev Med. 1995;46:371-9
pubmed: 7598472
Mol Cancer Res. 2019 Jul;17(7):1429-1434
pubmed: 31043490
J Pharmacol Exp Ther. 2018 Mar;364(3):494-503
pubmed: 29263244
Lancet Gastroenterol Hepatol. 2018 Apr;3(4):263-270
pubmed: 29397354
Med Sci Monit. 2016 Dec 06;22:4779-4785
pubmed: 27923017
Cancer Invest. 2017 Jul 3;35(6):386-392
pubmed: 28426267
Future Oncol. 2019 Aug;15(22):2571-2576
pubmed: 31407939
Immunity. 2006 Jul;25(1):153-62
pubmed: 16860764
Anticancer Res. 2002 Nov-Dec;22(6C):4183-6
pubmed: 12553053
J Clin Oncol. 2005 Aug 20;23(24):5474-83
pubmed: 16027439
Clin Cancer Res. 2015 Mar 15;21(6):1313-20
pubmed: 25589621
Exp Cell Res. 2019 Sep 1;382(1):111462
pubmed: 31194976
Expert Opin Ther Targets. 2012 Dec;16(12):1215-25
pubmed: 22978444
Clin Cancer Res. 2017 Sep 15;23(18):5339-5348
pubmed: 28611198
Front Immunol. 2021 Aug 30;12:729809
pubmed: 34526999
J Exp Clin Cancer Res. 2019 Dec 16;38(1):492
pubmed: 31842958
JAMA. 2018 Jun 26;319(24):2486-2496
pubmed: 29946728
Int J Radiat Biol. 2014 Aug;90(8):615-21
pubmed: 24527669
Cell Stem Cell. 2011 May 6;8(5):511-24
pubmed: 21419747
Cancer Treat Rev. 2018 Jan;62:50-60
pubmed: 29169144
Signal Transduct Target Ther. 2020 Mar 20;5(1):22
pubmed: 32296018
Lancet Oncol. 2015 Jun;16(6):619-29
pubmed: 25981818
Gastroenterology. 1993 May;104(5):1535-49
pubmed: 8482467
Nat Rev Cancer. 2011 Apr;11(4):254-67
pubmed: 21390059
Clin Lung Cancer. 2006 Jul;8(1):30-8
pubmed: 16870043
Clin Colorectal Cancer. 2018 Jun;17(2):e323-e329
pubmed: 29551560
Invest New Drugs. 2013 Oct;31(5):1283-93
pubmed: 23625328
Tumour Biol. 2008;29(3):137-44
pubmed: 18612218
Cancer Res. 2003 Sep 1;63(17):5209-12
pubmed: 14500346
J Clin Oncol. 2018 Feb 20;36(6):536-542
pubmed: 29320312
Cancer. 1993 Jun 1;71(11):3493-501
pubmed: 8387880
Mol Med Rep. 2016 Jun;13(6):5193-9
pubmed: 27121210
Chin J Cancer. 2017 Dec 22;36(1):97
pubmed: 29273089
Hum Gene Ther. 2019 Apr;30(4):402-412
pubmed: 30693795
PLoS One. 2011 Jan 25;6(1):e15561
pubmed: 21283624
Oxid Med Cell Longev. 2016;2016:5874127
pubmed: 27057280
Cancer Res. 2008 Jun 15;68(12):4774-82
pubmed: 18559524
Int J Cancer. 2011 Jul 1;129(1):245-55
pubmed: 21170960
J Immunol. 2020 Nov 15;205(10):2905-2915
pubmed: 33028620
Lancet Oncol. 2018 Aug;19(8):e388
pubmed: 29983343
ACS Med Chem Lett. 2019 Jan 14;10(4):499-503
pubmed: 30996786
Int Rev Cell Mol Biol. 2019;343:129-218
pubmed: 30712672
Chemistry. 2020 Jun 10;26(33):7416-7424
pubmed: 32083773
Eur J Cancer. 2013 Jun;49(9):2233-42
pubmed: 23478000
PLoS One. 2014 Jun 18;9(6):e99132
pubmed: 24941171
N Engl J Med. 2009 Apr 2;360(14):1408-17
pubmed: 19339720
Clin Colorectal Cancer. 2018 Jun;17(2):113-120
pubmed: 29174481
Oncologist. 2018 Jan;23(1):7-15
pubmed: 28894015
Onco Targets Ther. 2018 Jul 19;11:4137-4147
pubmed: 30050305
Arch Oral Biol. 2020 May;113:104710
pubmed: 32208194
Mol Cancer Res. 2018 Mar;16(3):378-389
pubmed: 29233910
Chem Biol. 2006 Nov;13(11):1235-42
pubmed: 17114005
Eur Respir J. 1989 May;2(5):461-9
pubmed: 2547647
Immunity. 2016 Feb 16;44(2):343-54
pubmed: 26872698
Oncogene. 2018 Jun;37(24):3301-3316
pubmed: 29551770
Clin Cancer Res. 2020 Nov 15;26(22):5887-5894
pubmed: 32694160
Biochemistry. 2007 Jul 31;46(30):8701-8
pubmed: 17620015
Cancer Med. 2020 Feb;9(4):1485-1494
pubmed: 31876399
Biofactors. 2012 Sep-Oct;38(5):338-48
pubmed: 22674855
Ann Oncol. 2018 Sep 1;29(9):1955-1963
pubmed: 30010751
Front Immunol. 2018 Oct 09;9:2100
pubmed: 30356816
Cancer Gene Ther. 2018 Dec;25(11-12):317-325
pubmed: 29915283
Clin Cancer Res. 2010 Jan 1;16(1):311-9
pubmed: 20028771
PLoS One. 2009 Sep 30;4(9):e7258
pubmed: 19789626
Clin Adv Hematol Oncol. 2019 Aug;17 Suppl 12(8):1-19
pubmed: 32720931
Neoplasia. 2005 Jun;7(6):545-55
pubmed: 16036105
J Clin Oncol. 2020 Jun 20;38(18):2053-2061
pubmed: 32343640
Front Oncol. 2016 Nov 01;6:233
pubmed: 27847783
BMC Cancer. 2014 Jul 11;14:510
pubmed: 25012508
Oncotarget. 2016 Mar 29;7(13):16158-71
pubmed: 26930714
Methods Mol Biol. 2021;2256:1-15
pubmed: 34014513
Cell Death Dis. 2016 Aug 11;7(8):e2337
pubmed: 27512958
J Intern Med. 2009 Jan;265(1):43-57
pubmed: 19093959
World J Gastroenterol. 2017 Apr 7;23(13):2337-2345
pubmed: 28428713
Ann Oncol. 2011 Sep;22(9):1958-1972
pubmed: 21307158
Drugs. 2015 Jan;75(1):129-39
pubmed: 25430078
Oncologist. 2019 Nov;24(11):1416-1419
pubmed: 31444293
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Am J Gastroenterol. 1999 Jan;94(1):41-6
pubmed: 9934729
Ann Oncol. 2016 Aug;27(8):1386-422
pubmed: 27380959
Cancer Lett. 2018 Jul 28;427:1-8
pubmed: 29678550
Mol Carcinog. 2019 Mar;58(3):321-333
pubmed: 30365189
Curr Pharm Biotechnol. 2018;19(1):5-18
pubmed: 29667553
J Immunother. 2015 Jan;38(1):1-11
pubmed: 25415283
Sci Transl Med. 2015 Nov 18;7(314):314ra186
pubmed: 26582901
Cancer Immunol Immunother. 2020 Sep;69(9):1781-1799
pubmed: 32347357
J Hematol Oncol. 2017 Jan 19;10(1):22
pubmed: 28103904
Nat Rev Clin Oncol. 2011 Feb;8(2):97-106
pubmed: 21151206
Oncogene. 2020 Nov;39(47):7019-7033
pubmed: 32999444
Semin Cancer Biol. 2008 Aug;18(4):260-7
pubmed: 18467123
Nature. 1981 Mar 19;290(5803):261-4
pubmed: 7207618
Lancet Oncol. 2020 Apr;21(4):497-507
pubmed: 32164906
Cancer Prev Res (Phila). 2013 Dec;6(12):1273-82
pubmed: 24154719
Biosci Rep. 2019 Mar 6;39(3):
pubmed: 30674639
Biomaterials. 2016 Oct;105:89-101
pubmed: 27512943
Stem Cells Transl Med. 2015 Sep;4(9):1033-43
pubmed: 26136504
Am J Cancer Res. 2019 May 01;9(5):945-958
pubmed: 31218103
Curr Treat Options Oncol. 2018 May 11;19(6):29
pubmed: 29752549
N Engl J Med. 2009 Feb 5;360(6):563-72
pubmed: 19196673
Clin Cancer Res. 2013 Feb 1;19(3):657-67
pubmed: 23251002
Curr Cancer Drug Targets. 2019;19(6):430-448
pubmed: 30073927
Cancer Biol Ther. 2014;15(12):1635-45
pubmed: 25482937
Science. 2017 Jul 28;357(6349):409-413
pubmed: 28596308
Ther Adv Med Oncol. 2021 Feb 22;13:1758835921992974
pubmed: 33747149
Mol Ther Nucleic Acids. 2014 Jun 24;3:e170
pubmed: 24959843
Cancer Lett. 2020 Apr 28;476:161-169
pubmed: 32105676
J Immunother. 2019 Feb/Mar;42(2):33-42
pubmed: 30586347
Biochem Pharmacol. 2019 Feb;160:110-120
pubmed: 30579838
Cancer Manag Res. 2019 Aug 16;11:7787-7803
pubmed: 31496821
Cancer Sci. 2011 Jul;102(7):1374-80
pubmed: 21443688
N Engl J Med. 2015 May 14;372(20):1909-19
pubmed: 25970050
PLoS One. 2017 Dec 28;12(12):e0189848
pubmed: 29284010