The Genetic Landscape of Patent Foramen Ovale: A Systematic Review.


Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
06 12 2021
Historique:
received: 06 11 2021
revised: 30 11 2021
accepted: 03 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 17 2 2022
Statut: epublish

Résumé

Patent Foramen Ovale (PFO) is a common postnatal defect of cardiac atrial septation. A certain degree of familial aggregation has been reported. Animal studies suggest the involvement of the Notch pathway and other cardiac transcription factors (GATA4, TBX20, NKX2-5) in Foramen Ovale closure. This review evaluates the contribution of genetic alterations in PFO development. We systematically reviewed studies that assessed rare and common variants in subjects with PFO. The protocol was registered with PROSPERO and followed MOOSE guidelines. We systematically searched English studies reporting rates of variants in PFO subjects until the 30th of June 2021. Among 1231 studies, we included four studies: two of them assessed the

Identifiants

pubmed: 34946902
pii: genes12121953
doi: 10.3390/genes12121953
pmc: PMC8700998
pii:
doi:

Substances chimiques

GATA4 Transcription Factor 0
GATA4 protein, human 0
Homeobox Protein Nkx-2.5 0
NKX2-5 protein, human 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Matteo Paolucci (M)

Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Neurology Unit, "M. Bufalini" Hospital, AUSL Romagna, Viale Giovanni Ghirotti, 286, 47521 Cesena, Italy.

Chiara Vincenzi (C)

Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, via Amendola 2, 42122 Reggio Emilia, Italy.

Michele Romoli (M)

Neurology Unit, "M. Bufalini" Hospital, AUSL Romagna, Viale Giovanni Ghirotti, 286, 47521 Cesena, Italy.

Giulia Amico (G)

Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
DINOGMI-Universite degli Studi di Genova, Largo P. Daneo,3, 16132 Genova, Italy.

Isabella Ceccherini (I)

Laboratory of Genetics and Genomics of Rare Diseases, IRCCS Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.

Simona Lattanzi (S)

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, 60121 Ancona, Italy.

Anna Bersano (A)

Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

Marco Longoni (M)

Neurology Unit, "M. Bufalini" Hospital, AUSL Romagna, Viale Giovanni Ghirotti, 286, 47521 Cesena, Italy.

Simona Sacco (S)

Neuroscience Section, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

Fabrizio Vernieri (F)

Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, Via Alvaro del Portillo, 200, 00128 Rome, Italy.

Rosario Pascarella (R)

Neuroradiology Unit, AUSL-IRCCS di Reggio Emilia, via Amendola 2, 42122 Reggio Emilia, Italy.

Franco Valzania (F)

Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, via Amendola 2, 42122 Reggio Emilia, Italy.

Marialuisa Zedde (M)

Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, via Amendola 2, 42122 Reggio Emilia, Italy.

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Classifications MeSH