Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the
Animals
Bone Neoplasms
/ genetics
Cyclin-Dependent Kinase Inhibitor p15
/ genetics
Cyclin-Dependent Kinase Inhibitor p16
/ genetics
Dog Diseases
/ genetics
Dogs
Genetic Loci
Genetic Predisposition to Disease
Genome
Genome-Wide Association Study
Osteosarcoma
/ genetics
Polymorphism, Single Nucleotide
CDKN2A/B
Leonberger
animal model
bone cancer
canis familiaris
osteosarcoma
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
09 12 2021
09 12 2021
Historique:
received:
07
11
2021
revised:
08
12
2021
accepted:
08
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
17
2
2022
Statut:
epublish
Résumé
Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We performed genome-wide association analysis with high-density imputed SNP genotype data from 273 Leonberger cases with a median age of 8.1 [3.1-13.5] years and 365 controls older than eight years. This analysis revealed significant associations at the
Identifiants
pubmed: 34946912
pii: genes12121964
doi: 10.3390/genes12121964
pmc: PMC8700858
pii:
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p15
0
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : K01 OD027058
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA225755
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA247088
Pays : United States
Références
Acta Vet Scand. 2017 Oct 24;59(1):71
pubmed: 29065898
Vet J. 2011 Sep;189(3):268-77
pubmed: 20889358
PLoS One. 2019 Dec 30;14(12):e0223243
pubmed: 31887114
Can J Vet Res. 2007 Oct;71(4):292-9
pubmed: 17955904
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Nat Genet. 2012 Jun 17;44(7):821-4
pubmed: 22706312
Vet Sci. 2015 Aug 17;2(3):210-230
pubmed: 29061942
Genomics. 2010 Oct;96(4):220-7
pubmed: 20647041
BMC Vet Res. 2012 May 15;8:56
pubmed: 22587466
Anticancer Res. 2007 Jan-Feb;27(1A):155-64
pubmed: 17352227
Am J Hum Genet. 2012 Dec 7;91(6):1011-21
pubmed: 23217325
J Comp Pathol. 2020 Oct;180:91-99
pubmed: 33222881
Virchows Arch. 2020 Jan;476(1):147-157
pubmed: 31741049
PLoS Genet. 2021 Apr 1;17(4):e1009395
pubmed: 33793571
Genes (Basel). 2020 Nov 27;11(12):
pubmed: 33261176
Am J Hum Genet. 2007 Nov;81(5):1084-97
pubmed: 17924348
Cell Rep. 2014 Apr 10;7(1):104-12
pubmed: 24703847
Genet Sel Evol. 2020 Oct 14;52(1):61
pubmed: 33054768
Canine Med Genet. 2021 Mar 10;8(1):2
pubmed: 33750475
G3 (Bethesda). 2021 Oct 19;11(11):
pubmed: 34849780
BMC Genomics. 2019 Mar 19;20(1):226
pubmed: 30890123
Cancer. 2009 Apr 1;115(7):1531-43
pubmed: 19197972
Medicine (Baltimore). 2018 Sep;97(38):e12525
pubmed: 30235774
PLoS Genet. 2015 Apr 07;11(4):e1004969
pubmed: 25849665
Genomics. 2007 Sep;90(3):354-63
pubmed: 17628392
Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1019-27
pubmed: 22623710
Front Vet Sci. 2021 Apr 26;8:660435
pubmed: 33981746
Nature. 2010 Apr 8;464(7290):898-902
pubmed: 20237475
Cancer Res. 2018 Jul 1;78(13):3421-3431
pubmed: 29724721
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Mol Cancer Res. 2019 Dec;17(12):2410-2421
pubmed: 31570656
Genome Biol. 2013 Dec 12;14(12):R132
pubmed: 24330828
Canine Med Genet. 2021 Oct 9;8(1):9
pubmed: 34627404
Annu Rev Anim Biosci. 2019 Feb 15;7:449-472
pubmed: 30418802