Polymorphisms in Genes Involved in Osteoblast Differentiation and Function Are Associated with Anthropometric Phenotypes in Spanish Women.
Absorptiometry, Photon
Aged
Allelic Imbalance
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Body Mass Index
Bone Density
Cell Differentiation
Cohort Studies
Female
Forkhead Transcription Factors
/ genetics
Genetic Association Studies
Humans
MEF2 Transcription Factors
/ genetics
Middle Aged
Osteoblasts
/ physiology
Polymorphism, Single Nucleotide
Spain
Waist Circumference
beta Catenin
/ genetics
BMD
BMI
CTNNB1 and MEF2C genes
osteoporosis
women
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
17 12 2021
17 12 2021
Historique:
received:
10
11
2021
revised:
09
12
2021
accepted:
11
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Much of the genetic variance associated with osteoporosis is still unknown. Bone mineral density (BMD) is the main predictor of osteoporosis risk, although other anthropometric phenotypes have recently gained importance. The aim of this study was to analyze the association of SNPs in genes involved in osteoblast differentiation and function with BMD, body mass index (BMI), and waist (WC) and hip (HC) circumferences. Four genes that affect osteoblast differentiation and/or function were selected from among the differentially expressed genes in fragility hip fracture (
Identifiants
pubmed: 34946961
pii: genes12122012
doi: 10.3390/genes12122012
pmc: PMC8701034
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
CTNNB1 protein, human
0
EBF2 protein, human
0
FOXC1 protein, human
0
Forkhead Transcription Factors
0
MEF2 Transcription Factors
0
MEF2C protein, human
0
beta Catenin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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