Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants.
cationic surfactants
nanoemulsions
ocular barriers
ocular delivery
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
08 Dec 2021
08 Dec 2021
Historique:
received:
21
10
2021
revised:
03
12
2021
accepted:
06
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailability of drugs for the treatment of eye diseases, in particular those affecting the posterior segment. In this review, we address the main factors that govern the development of a suitable nanoemulsion formulation for eye administration to increase the patient's compliance to the treatment. Appropriate lipid composition and type of surfactants (with a special emphasis on cationic compounds) are discussed, together with manufacturing techniques and characterization methods that are instrumental for the development of appropriate ophthalmic nanoemulsions.
Identifiants
pubmed: 34947136
pii: ma14247541
doi: 10.3390/ma14247541
pmc: PMC8706710
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE) of the EU, for the scholarship SFRH/BD/130555/2017 granted to A. R. Fernandes, and for the projects UIDB/04469/2020 (CEB str
ID : SFRH/BD/130555/2017, UIDB/04469/2020 (CEB strategic fund) and UIDB/04033/2020 (CITAB)
Références
J Pharm Sci. 1983 Nov;72(11):1266-72
pubmed: 6139471
J Pharm Sci. 1996 May;85(5):530-6
pubmed: 8742946
AAPS PharmSciTech. 2009;10(1):69-76
pubmed: 19148761
J Colloid Interface Sci. 2013 Dec 1;411:105-13
pubmed: 24050638
Drug Deliv. 2016 Nov;23(9):3712-3723
pubmed: 27689408
Br J Ophthalmol. 2008 Oct;92(10):1415-8
pubmed: 18815423
J Control Release. 2014 Sep 28;190:172-81
pubmed: 24998941
Pharmaceutics. 2021 Oct 10;13(10):
pubmed: 34683945
Int J Pharm. 2013 Feb 25;443(1-2):293-305
pubmed: 23333217
J Ocul Pharmacol Ther. 2020 Jul/Aug;36(6):342-354
pubmed: 32255728
Exp Eye Res. 2004 Mar;78(3):513-25
pubmed: 15106930
Sci Rep. 2018 Jun 22;8(1):9502
pubmed: 29934624
Pharmaceutics. 2019 Jul 09;11(7):
pubmed: 31324063
Soft Matter. 2016 Mar 21;12(11):2826-41
pubmed: 26924445
Nanomedicine. 2012 Aug;8(6):1034-41
pubmed: 22115598
Int J Pharm. 2010 Jun 30;393(1-2):167-75
pubmed: 20362042
Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1097-102
pubmed: 18670109
Pharm Sci Technol Today. 1999 Apr;4(2):134-143
pubmed: 10322370
Expert Opin Drug Deliv. 2020 Apr;17(4):603-619
pubmed: 32105151
Pharmaceutics. 2021 Sep 17;13(9):
pubmed: 34575567
Int J Pharm. 2006 Apr 7;312(1-2):174-8
pubmed: 16472951
Exp Eye Res. 2001 Nov;73(5):581-92
pubmed: 11747359
J Adv Pharm Technol Res. 2013 Oct;4(4):210-6
pubmed: 24350052
J Microencapsul. 2009 Mar;26(2):180-6
pubmed: 18608806
Drug Dev Ind Pharm. 2017 Feb;43(2):275-282
pubmed: 27645109
Acta Pharm. 2019 Dec 1;69(4):621-634
pubmed: 31639085
Mol Pharm. 2021 Oct 4;18(10):3719-3740
pubmed: 34533317
Int J Pharm. 2020 Feb 15;575:118953
pubmed: 31843548
Invest Ophthalmol Vis Sci. 1992 Mar;33(3):581-95
pubmed: 1544784
J Adv Pharm Technol Res. 2011 Jul;2(3):192-4
pubmed: 22171317
PLoS One. 2015 Jun 25;10(6):e0126614
pubmed: 26110864
Ann Clin Lab Sci. 2010 Spring;40(2):115-25
pubmed: 20421622
Int J Mol Sci. 2017 Jul 18;18(7):
pubmed: 28718823
Pharm Res. 2009 Jul;26(7):1785-91
pubmed: 19384462
Invest Ophthalmol. 1973 Sep;12(9):654-68
pubmed: 4582462
J Control Release. 2018 Jan 28;270:203-225
pubmed: 29199062
Prog Retin Eye Res. 2001 Nov;20(6):799-821
pubmed: 11587918
J Control Release. 2017 Apr 28;252:28-49
pubmed: 28279798
J Drug Deliv. 2012;2012:604204
pubmed: 22506123
Anal Chem. 2020 May 19;92(10):7071-7078
pubmed: 32316720
J Control Release. 2012 Jun 10;160(2):225-31
pubmed: 22138070
Biomed Pharmacother. 1999 May;53(4):193-206
pubmed: 10392291
Int J Pharm. 2010 Mar 30;388(1-2):107-13
pubmed: 20045044
Pain. 1982 Oct;14(2):105-120
pubmed: 7177676
Biomaterials. 2013 Jan;34(2):481-91
pubmed: 23083930
Saudi Pharm J. 2015 Apr;23(2):188-94
pubmed: 25972740
Int J Dev Biol. 2007;51(8):739-43
pubmed: 17939121
Drug Discov Today. 2008 Feb;13(3-4):144-51
pubmed: 18275912
Expert Opin Biol Ther. 2003 Feb;3(1):45-56
pubmed: 12718730
Int J Mol Sci. 2019 Nov 06;20(22):
pubmed: 31698783
Indian J Pharm Sci. 2011 Nov;73(6):615-20
pubmed: 23112394
Adv Drug Deliv Rev. 2008 Mar 17;60(6):757-67
pubmed: 18096269
Drug Dev Ind Pharm. 2013 May;39(5):780-90
pubmed: 22873799
J Cataract Refract Surg. 2011 Mar;37(3):588-98
pubmed: 21333881
Eur J Pharm Biopharm. 2017 Jan;110:58-69
pubmed: 27789359
Pharm Dev Technol. 2019 Jun;24(5):600-606
pubmed: 30472913
Clin Exp Optom. 2012 Jan;95(1):3-11
pubmed: 22022802
Curr Eye Res. 1988 May;7(5):483-6
pubmed: 3409715
Prog Retin Eye Res. 1998 Jan;17(1):33-58
pubmed: 9537794
Nat Mater. 2012 Feb 12;11(4):344-52
pubmed: 22327746
Antioxidants (Basel). 2021 Jan 11;10(1):
pubmed: 33440661
J Pharm Sci. 1979 Jun;68(6):673-84
pubmed: 458563
Int J Pharm. 2009 Jul 30;377(1-2):142-7
pubmed: 19454306
J Pharm Sci. 2012 Feb;101(2):707-25
pubmed: 22012873
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4506-14
pubmed: 18503001
Pharm Res. 1995 May;12(5):687-92
pubmed: 7479554
Eye (Lond). 2001 Jun;15(Pt 3):384-9
pubmed: 11450762
Prog Retin Eye Res. 2011 Nov;30(6):471-92
pubmed: 21820076
Int J Pharm. 2005 Sep 14;301(1-2):121-8
pubmed: 16023810
Trans Am Ophthalmol Soc. 2006;104:264-302
pubmed: 17471348
Eur J Pharm Biopharm. 2005 Jul;60(2):207-25
pubmed: 15939234
Int J Mol Sci. 2013 May 10;14(5):9906-46
pubmed: 23665898
Nanomaterials (Basel). 2020 Apr 10;10(4):
pubmed: 32290252
Biomaterials. 2006 Mar;27(8):1670-8
pubmed: 16199085
Nanomaterials (Basel). 2021 Oct 18;11(10):
pubmed: 34685199
Arch Pharm Res. 2003 Sep;26(9):768-72
pubmed: 14560928
Adv Colloid Interface Sci. 2021 Jan;287:102318
pubmed: 33242713
Int J Pharm. 2008 Jun 24;358(1-2):285-91
pubmed: 18455333
Eur J Pharm Sci. 2020 Mar 1;144:105229
pubmed: 31958581
Crit Rev Food Sci Nutr. 2011 Apr;51(4):285-330
pubmed: 21432697
Physiol Rev. 2005 Jul;85(3):845-81
pubmed: 15987797
Ophthalmology. 1999 Sep;106(9):1697-704
pubmed: 10485537
Int J Pharm. 2020 Feb 25;576:118979
pubmed: 31870964
Br J Ophthalmol. 2005 Feb;89(2):243-4
pubmed: 15665364
J Control Release. 2020 Dec 10;328:895-916
pubmed: 33069743
Int J Pharm. 2002 Feb 21;233(1-2):159-67
pubmed: 11897420
Pharmaceutics. 2021 Mar 25;13(4):
pubmed: 33805986
J Pharm Sci. 1993 Nov;82(11):1069-79
pubmed: 8289116
Eur J Pharm Sci. 2018 Mar 30;115:233-239
pubmed: 29414307
Int J Pharm. 2013 Jan 20;440(2):126-34
pubmed: 23078859
J Appl Microbiol. 2002;93(2):302-9
pubmed: 12147079