Low-Level Elevations of Procalcitonin Are Associated with Increased Mortality in Acute Heart Failure Patients, Independent of Concomitant Infection.
AHF
NT-proBNP
PCT
all-cause mortality
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
18 Dec 2021
18 Dec 2021
Historique:
received:
30
11
2021
accepted:
15
12
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
We aimed to evaluate the prognostic value of procalcitonin (PCT) in acute heart failure (AHF) patients, especially in those without underlying infection. We enrolled patients presenting with acute dyspnea to the emergency department (ED) of Heidelberg University Hospital and studied the prognostic role of PCT on all-cause death. Of 312 patients, AHF was diagnosed in 139 patients. Of these, 125 patients had AHF without signs of infection, and 14 had AHF complicated by respiratory or other infection. The optimal prognostic PCT cutoff value for mortality prediction was calculated by a receiver operating characteristics curve. In patients with AHF, the prognostic PCT cutoff value was 0.08 ng/mL. The Kaplan-Meier survival analysis showed that AHF patients with PCT values > 0.08 ng/mL had a higher all-cause mortality at 120 days than those with PCT values ≤ 0.08 ng/mL (log-rank
Identifiants
pubmed: 34947960
pii: life11121429
doi: 10.3390/life11121429
pmc: PMC8706732
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondation Coeur - Daniel Wagner, Fondation de Luxembourg
ID : n/a
Références
Clin Chem. 2004 Jan;50(1):234-6
pubmed: 14709661
Crit Care. 2010;14(6):R206
pubmed: 21083886
Am J Cardiol. 1997 May 15;79(10):1426-30
pubmed: 9165177
BMC Infect Dis. 2007 Mar 02;7:10
pubmed: 17335562
Chest. 2010 Jul;138(1):121-9
pubmed: 20299634
Eur J Heart Fail. 2008 Apr;10(4):396-403
pubmed: 18353715
Clin Chem. 1993 Apr;39(4):561-77
pubmed: 8472349
Int J Cardiol. 2014 Aug 20;175(3):464-72
pubmed: 25005339
Infection. 2007 Oct;35(5):352-5
pubmed: 17882355
Crit Care. 2014 Jan 06;18(1):R4
pubmed: 24393388
Eur J Heart Fail. 2020 Feb;22(2):267-275
pubmed: 31833168
N Engl J Med. 1990 Jul 26;323(4):236-41
pubmed: 2195340
Eur J Heart Fail. 2004 Mar 15;6(3):301-8
pubmed: 14987580
Am J Cardiol. 2013 Feb 15;111(4):493-8
pubmed: 23218997
J Am Coll Cardiol. 2008 Aug 12;52(7):534-40
pubmed: 18687247
Eur J Intern Med. 2015 Jan;26(1):42-8
pubmed: 25592074
Int J Cardiol. 2014 Dec 15;177(2):532-4
pubmed: 25194863
Circulation. 2003 Mar 25;107(11):1486-91
pubmed: 12654604
Am J Respir Crit Care Med. 2006 Jul 1;174(1):84-93
pubmed: 16603606
Circulation. 1995 Sep 15;92(6):1479-86
pubmed: 7664430
J Am Coll Cardiol. 2010 May 11;55(19):2062-76
pubmed: 20447528
J Card Fail. 2007 Feb;13(1):42-9
pubmed: 17339002
Clin Chem. 2006 May;52(5):827-31
pubmed: 16543387
Eur J Heart Fail. 2011 Jul;13(7):718-25
pubmed: 21551163
Circulation. 2000 Dec 19;102(25):3060-7
pubmed: 11120695
ESC Heart Fail. 2017 Aug;4(3):203-208
pubmed: 28772049
Virulence. 2010 Mar-Apr;1(2):88-92
pubmed: 21178422
ESC Heart Fail. 2017 Aug;4(3):232-240
pubmed: 28772028
Am J Cardiol. 2005 Apr 15;95(8):948-54
pubmed: 15820160
J Am Coll Cardiol. 2018 Mar 20;71(11):1191-1200
pubmed: 29544601
Am Heart J. 2006 Jan;151(1):48-54
pubmed: 16368291
J Am Coll Cardiol. 2003 Aug 20;42(4):728-35
pubmed: 12932611
Int J Cardiol. 2017 Jan 1;226:53-59
pubmed: 27788390
Eur Respir J. 2011 Feb;37(2):384-92
pubmed: 20595156
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
Int J Cardiol. 2016 Feb 1;204:164-71
pubmed: 26666342
J Am Coll Cardiol. 2007 Nov 13;50(20):1973-80
pubmed: 17996563
J Infect Dis. 2000 Jan;181(1):176-80
pubmed: 10608764
Lancet. 1999 May 29;353(9167):1838-42
pubmed: 10359409