Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Restored Oxidative Stress-Related Impaired Osteogenic Differentiation.

Antioxidants / pharmacology Apoptosis / drug effects Bone Marrow Cells / cytology Cell Differentiation / drug effects Cell Proliferation / drug effects Cells, Cultured Culture Media, Conditioned / pharmacology Humans Mesenchymal Stem Cells / metabolism Osteogenesis / drug effects Oxidative Stress / drug effects Reactive Oxygen Species / metabolism
antioxidant conditioned medium mesenchymal stem cells osteogenic differentiation oxidative stress

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
15 Dec 2021
Historique:
received: 31 10 2021
revised: 29 11 2021
accepted: 10 12 2021
entrez: 24 12 2021
pubmed: 25 12 2021
medline: 1 2 2022
Statut: epublish

Résumé

Oxidative stress from high levels of intracellular reactive oxygen species (ROS) has been linked to various bone diseases. Previous studies indicate that mesenchymal stem cells (MSC) secrete bioactive factors (conditioned medium (MSC-CM)) that have antioxidant effects. However, the antioxidant role of MSC-CM on osteogenesis has not been fully studied. We aimed to identify antioxidant proteins in MSC-CM using mass spectrometry-based proteomics and to explore their effects on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSC) exposed to oxidative stress induced by hydrogen peroxide (H

Identifiants

DOI: 10.3390/ijms222413458 PMID: 34948255 PMC: PMC8706339
pubmed: 34948255
pii: ijms222413458
doi: 10.3390/ijms222413458
pmc: PMC8706339
pii:
doi:

Substances chimiques

Antioxidants 0
Culture Media, Conditioned 0
Reactive Oxygen Species 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Trond Mohn Foundation
ID : BFS2018TMT10

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Auteurs

Ragda Saleem (R)

Center of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
Centre for International Health, University of Bergen, 5009 Bergen, Norway.

Samih Mohamed-Ahmed (S)

Center of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

Rammah Elnour (R)

Department of Clinical Medicine, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

Ellen Berggreen (E)

Oral Health Centre of Expertise in Western Norway, 5009 Bergen, Norway.
Department of Biomedicine, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

Kamal Mustafa (K)

Center of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

Niyaz Al-Sharabi (N)

Center of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Cellules › Cellules cultivées › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Équipement et fournitures › Milieux de culture › Milieux de culture conditionnés › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Conditioned Medium from Bone Marrow...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Conditioned Medium from Bone Marrow...