Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.
Journal
The ISME journal
ISSN: 1751-7370
Titre abrégé: ISME J
Pays: England
ID NLM: 101301086
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
31
08
2021
accepted:
16
12
2021
revised:
07
12
2021
pubmed:
25
12
2021
medline:
28
4
2022
entrez:
24
12
2021
Statut:
ppublish
Résumé
We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
Identifiants
pubmed: 34949784
doi: 10.1038/s41396-021-01179-3
pii: 10.1038/s41396-021-01179-3
pmc: PMC9038732
doi:
Substances chimiques
DNA Transposable Elements
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1473-1477Informations de copyright
© 2022. The Author(s).
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