Development of Chitosan-Based Nanoemulsion Gel Containing Microbial Secondary Metabolite with Effective Antifungal Activity: In vitro and in vivo Characterizations.
Pseudomonas fluorescens
fungal resistance
microbial secondary metabolites
nanoemulsion gel
phthalic acid ester derivative
red soil
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
09
2021
accepted:
23
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Microbial resistance to antibiotics is one of the most important public health concerns of the 21 Three compounds were isolated and purified of which only one compound (Pure 2) showed potent antifungal activity (MFC: 8-132 µg/mL), which was also significantly ( NMR analyses identified the compound as a derivative of phthalic acid ester (PAE). The optimized formulations displayed a droplet size <100 nm, -ve zeta potential, and PDI <0.45. The drug content was within the official limit of pharmacopeia (ie, 100±10%). Insignificant changes ( Hence, the NEG-loaded PAE isolated from
Identifiants
pubmed: 34949923
doi: 10.2147/IJN.S338064
pii: 338064
pmc: PMC8689013
doi:
Substances chimiques
Antifungal Agents
0
Emulsions
0
Chitosan
9012-76-4
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
8203-8219Commentaires et corrections
Type : RetractionIn
Informations de copyright
© 2021 Khan et al.
Déclaration de conflit d'intérêts
Farid Menaa is employed by the California Innovations Corporation, San Diego, CA, 92037, USA. The authors declare no other potential conflicts of interest for this work nor in submission of this manuscript.
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