Computational Modelling of Glucose Uptake by SGLT1 and Apical GLUT2 in the Enterocyte.
CellML
OpenCOR
epithelial transport
glucose absorption
nutrient absorption
type 2 diabetes
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
04
2021
accepted:
04
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
It has been suggested that glucose absorption in the small intestine depends on both constitutively expressed SGLT1 and translocated GLUT2 in the brush border membrane, especially in the presence of high levels of luminal glucose. Here, we present a computational model of non-isotonic glucose uptake by small intestinal epithelial cells. The model incorporates apical uptake
Identifiants
pubmed: 34950044
doi: 10.3389/fphys.2021.699152
pmc: PMC8688934
doi:
Types de publication
Journal Article
Langues
eng
Pagination
699152Informations de copyright
Copyright © 2021 Afshar, Safaei, Nickerson, Hunter and Suresh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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