Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review.
expression
lncRNAs
multiple sclerosis
neurodegenerative disease
polymorphism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
09
2021
accepted:
08
11
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
11
2
2022
Statut:
epublish
Résumé
Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death
Identifiants
pubmed: 34950142
doi: 10.3389/fimmu.2021.774002
pmc: PMC8688805
doi:
Substances chimiques
Biomarkers
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
774002Informations de copyright
Copyright © 2021 Jalaiei, Asadi, Sabaie, Dehghani, Gharesouran, Hussen, Taheri, Ghafouri-Fard and Rezazadeh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Oxid Med Cell Longev. 2017;2017:2062384
pubmed: 28811863
Br J Pharmacol. 2017 Dec;174(24):4684-4700
pubmed: 28736855
Mol Ther Nucleic Acids. 2018 Sep 7;12:393-404
pubmed: 30195777
Hum Mol Genet. 2019 May 1;28(9):1414-1428
pubmed: 30566690
Mol Cell. 2008 Mar 14;29(5):588-99
pubmed: 18249148
Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):3267-3273
pubmed: 32271444
J Immunol. 2013 Dec 1;191(11):5441-50
pubmed: 24166976
Crit Rev Immunol. 2013;33(4):283-306
pubmed: 23971528
Nat Immunol. 2006 Sep;7(9):946-53
pubmed: 16906165
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72
pubmed: 19571010
Mult Scler. 1999 Apr;5(2):101-4
pubmed: 10335518
Clin Immunol. 2017 Oct;183:121-131
pubmed: 28822831
J Neuroimmunol. 2018 Nov 15;324:129-135
pubmed: 30170791
Autoimmun Rev. 2015 Sep;14(9):798-805
pubmed: 25989481
Neuromolecular Med. 2020 Mar;22(1):111-120
pubmed: 31576494
Gene. 2021 Feb 15;769:145236
pubmed: 33068674
Oncotarget. 2015 Aug 21;6(24):20404-18
pubmed: 26246469
Metab Brain Dis. 2019 Aug;34(4):1201-1205
pubmed: 31049796
Cell Physiol Biochem. 2018;45(5):1986-1998
pubmed: 29518786
J Adv Res. 2019 Nov 04;21:141-150
pubmed: 32071782
J Neuroimmunol. 2019 Mar 15;328:50-59
pubmed: 30583215
J Immunol. 2018 Mar 1;200(5):1618-1626
pubmed: 29378913
Curr Protoc Bioinformatics. 2016 Jun 20;54:1.30.1-1.30.33
pubmed: 27322403
CNS Neurosci Ther. 2016 Apr;22(4):298-305
pubmed: 26842313
Neurosci Lett. 2019 May 14;701:54-57
pubmed: 30790644
Sci Rep. 2018 May 4;8(1):7018
pubmed: 29728583
Immunol Invest. 2019 Jul;48(5):549-554
pubmed: 30822187
Med Sci Monit. 2018 Jun 14;24:4054-4063
pubmed: 29900929
Nat Med. 2002 May;8(5):500-8
pubmed: 11984595
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1002-7
pubmed: 24371310
Nat Rev Genet. 2016 Jan;17(1):47-62
pubmed: 26666209
J Mol Neurosci. 2016 May;59(1):18-23
pubmed: 27034068
J Leukoc Biol. 2016 Jan;99(1):31-44
pubmed: 26538526
Cells. 2019 Jun 04;8(6):
pubmed: 31167379
J Neuroinflammation. 2021 May 11;18(1):108
pubmed: 33971906
Neurol Sci. 2020 Mar;41(3):561-568
pubmed: 31713760
Nucleic Acids Res. 2011 Jan;39(Database issue):D146-51
pubmed: 21112873
Exp Biol Med (Maywood). 2016 Mar;241(6):644-9
pubmed: 26748401
ACS Chem Neurosci. 2020 Jun 3;11(11):1651-1660
pubmed: 32348112
Nat Rev Dis Primers. 2018 Nov 8;4(1):44
pubmed: 30410088
Int J Mol Cell Med. 2018 Spring;7(2):102-110
pubmed: 30276165
Nat Immunol. 2009 May;10(5):514-23
pubmed: 19305396
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3883-92
pubmed: 26150504
Immunobiology. 2019 Jul;224(4):560-564
pubmed: 31003831
Am J Reprod Immunol. 2017 Jun;77(6):
pubmed: 28185352
Nat Biotechnol. 2012 Mar 25;30(5):453-9
pubmed: 22446693
Endocr Rev. 2015 Feb;36(1):25-64
pubmed: 25426780
Mediators Inflamm. 2015;2015:475158
pubmed: 26770017
Int J Oncol. 2016 Apr;48(4):1590-8
pubmed: 26892468
Cell J. 2020 Jul;22(2):165-170
pubmed: 31721530
J Neurol Sci. 2017 Feb 15;373:95-99
pubmed: 28131238
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
Nucleosides Nucleotides Nucleic Acids. 2021;40(2):157-165
pubmed: 33161812
Nat Immunol. 2001 Dec;2(12):1174-82
pubmed: 11694881
J Mol Neurosci. 2020 Jul;70(7):1050-1055
pubmed: 32100228
EMBO Rep. 2017 Oct;18(10):1801-1816
pubmed: 28808113
Int Immunopharmacol. 2017 Jun;47:141-149
pubmed: 28395256
Immunology. 2018 Apr;153(4):479-487
pubmed: 29030863
J Mol Neurosci. 2019 Mar;67(3):434-440
pubmed: 30610590
Acta Neuropathol Commun. 2020 Mar 19;8(1):35
pubmed: 32192527
Mol Cell. 2014 Feb 6;53(3):393-406
pubmed: 24507715
Int J Neurosci. 2020 Apr;130(4):407-412
pubmed: 31724909
Front Cell Neurosci. 2017 Jun 30;11:175
pubmed: 28713244
Cell Mol Biol Lett. 2018 Sep 3;23:43
pubmed: 30202418
Trends Genet. 2015 May;31(5):239-51
pubmed: 25869999
Int J Neurosci. 2019 Dec;129(12):1256-1260
pubmed: 31474168
Oncotarget. 2017 Jul 25;8(30):49409-49420
pubmed: 28472763
Science. 2014 Apr 18;344(6181):310-3
pubmed: 24744378
Mol Immunol. 2020 Sep;125:32-42
pubmed: 32629323
J Mol Neurosci. 2018 May;65(1):54-59
pubmed: 29713948
J Mol Neurosci. 2017 Dec;63(3-4):333-341
pubmed: 28967047
CNS Neurol Disord Drug Targets. 2015;14(2):157-67
pubmed: 25613507
Semin Neurol. 2018 Apr;38(2):212-225
pubmed: 29791948
Nucleic Acids Res. 2018 Jan 4;46(D1):D308-D314
pubmed: 29140524
J Immunol. 2008 Sep 1;181(5):3346-52
pubmed: 18714006
Neurol Sci. 2019 Apr;40(4):801-811
pubmed: 30680474
BMC Neurosci. 2010 Feb 05;11:14
pubmed: 20137068
J Immunol. 2010 Jun 15;184(12):6929-37
pubmed: 20483774
Mult Scler Relat Disord. 2020 May;40:101986
pubmed: 32058948
FASEB J. 2017 Feb;31(2):519-525
pubmed: 27756768
Genomics. 2007 Sep;90(3):397-406
pubmed: 17629449
Open Rheumatol J. 2012;6:259-72
pubmed: 23028410
Int J Biochem Cell Biol. 2014 Oct;55:304-10
pubmed: 25263529
J Cell Biochem. 2018 Jan;119(1):223-236
pubmed: 28608608
J Diabetes Complications. 2018 Mar;32(3):258-265
pubmed: 29398326
Life Sci. 2019 Sep 15;233:116731
pubmed: 31394128
RNA Biol. 2013 Jun;10(6):925-33
pubmed: 23696037
BMC Genomics. 2007 Mar 15;8:74
pubmed: 17362513
Clin Rev Allergy Immunol. 2016 Jun;50(3):333-44
pubmed: 26969025
Neurosci Lett. 2017 Mar 6;642:174-178
pubmed: 28174058
Int J Neurosci. 2020 May;130(5):515-521
pubmed: 31790618
Gene. 2019 Aug 20;710:140-144
pubmed: 31132513
J Immunol. 2012 Sep 1;189(5):2084-8
pubmed: 22851706
Mol Neurobiol. 2017 Apr;54(3):2012-2021
pubmed: 26910817
Virus Res. 2016 Jan 2;212:146-60
pubmed: 26166759
J Cell Physiol. 2019 Dec;234(12):22153-22162
pubmed: 31066039
EMBO Rep. 2008 Jun;9(6):569-75
pubmed: 18483487
Biochem Pharmacol. 2018 Sep;155:110-123
pubmed: 29944870
Nat Immunol. 2007 Sep;8(9):942-9
pubmed: 17676045
Curr Alzheimer Res. 2016;13(11):1219-1231
pubmed: 27338628
Curr Opin Neurol. 2015 Jun;28(3):206-19
pubmed: 25887768
Iran J Allergy Asthma Immunol. 2018 Dec 04;17(6):548-556
pubmed: 30644699
iScience. 2019 Jan 25;11:466-473
pubmed: 30661002
Mol Psychiatry. 2014 Apr;19(4):486-94
pubmed: 23628989
J Mol Neurosci. 2021 Apr;71(4):821-825
pubmed: 32951137
J Mol Neurosci. 2020 Oct;70(10):1533-1540
pubmed: 32578033
Nat Rev Mol Cell Biol. 2018 Mar;19(3):143-157
pubmed: 29138516
Gene. 2020 Oct 20;758:144962
pubmed: 32687946
Mult Scler. 2010 Oct;16(10):1178-88
pubmed: 20656764
Mult Scler Relat Disord. 2018 Oct;25:219-226
pubmed: 30114626
J Cell Physiol. 2019 Aug;234(10):17351-17360
pubmed: 30815864
Gene. 2012 Mar 15;496(1):8-16
pubmed: 22285928
Innate Immun. 2012 Dec;18(6):846-55
pubmed: 22522429
J Mol Neurosci. 2021 Jan;71(1):80-88
pubmed: 32613554
J Orthop Surg Res. 2020 Feb 3;15(1):38
pubmed: 32013985
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2525-30
pubmed: 19188602
Annu Rev Immunol. 2012;30:39-68
pubmed: 22136167
Neuromolecular Med. 2020 Mar;22(1):100-110
pubmed: 31482275
Brain. 2009 Dec;132(Pt 12):3329-41
pubmed: 19933767
Biosci Rep. 2019 Jan 15;39(1):
pubmed: 30514825
Nat Med. 2019 Aug;25(8):1290-1300
pubmed: 31332391
Nat Immunol. 2013 Nov;14(11):1190-8
pubmed: 24056746
Oncotarget. 2017 Apr 4;8(14):23650-23663
pubmed: 28423570
Int J Surg. 2010;8(5):336-41
pubmed: 20171303