Vitamin D Endocrine System and COVID-19.
ACUTE RESPIRATORY DISTRESS SYNDROME
CALCIFEDIOL
COVID‐19
INTENSIVE CARE TREATMENT
MORTALITY
VITAMIN D
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
31
07
2021
revised:
25
10
2021
accepted:
31
10
2021
entrez:
24
12
2021
pubmed:
25
12
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Preclinical data strongly suggest that the vitamin D endocrine system (VDES) may have extraskeletal effects. Cells of the immune and cardiovascular systems and lungs can express the vitamin D receptor, and overall these cells respond in a coherent fashion when exposed to 1,25-dihydroxyvitamin D, the main metabolite of the VDES. Supplementation of vitamin D-deficient subjects may decrease the risk of upper respiratory infections. The VDES also has broad anti-inflammatory and anti-thrombotic effects, and other mechanisms argue for a potential beneficial effect of a good vitamin D status on acute respiratory distress syndrome, a major complication of this SARS-2/COVID-19 infection. Activation of the VDES may thus have beneficial effects on the severity of COVID-19. Meta-analysis of observational data show that a better vitamin D status decreased the requirement of intensive care treatment or decreased mortality. A pilot study in Cordoba indicated that admission to intensive care was drastically reduced by administration of a high dose of calcifediol early after hospital admission for COVID-19. A large observational study in Barcelona confirmed that such therapy significantly decreased the odds ratio (OR) of mortality (OR = 0.52). This was also the conclusion of a retrospective study in five hospitals of Southern Spain. A retrospective study on all Andalusian patients hospitalized because of COVID-19, based on real-world data from the health care system, concluded that prescription of calcifediol (hazard ratio [HR] = 0.67) or vitamin D (HR = 0.75), 15 days before hospital admission decreased mortality within the first month. In conclusion, a good vitamin D status may have beneficial effects on the course of COVID-19. This needs to be confirmed by large, randomized trials, but in the meantime, we recommend (rapid) correction of 25 hydroxyvitamin D (25OHD) deficiency in subjects exposed to this coronavirus. © 2021 The Authors.
Identifiants
pubmed: 34950831
doi: 10.1002/jbm4.10576
pii: JBM410576
pmc: PMC8674769
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10576Informations de copyright
© 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Déclaration de conflit d'intérêts
RB received small lecture fees from Abiogen (Italy), FAES‐Farma (Spain), and Fresenius (Germany). JMQG received small lecture fees from Amgen (Spain) and FAES‐Farma (Spain).
Références
Autophagy. 2008 Oct;4(7):947-8
pubmed: 18769161
Int J Gen Med. 2014 Jun 19;7:303-9
pubmed: 24971035
JAMA. 2018 Feb 20;319(7):698-710
pubmed: 29466596
PLoS Pathog. 2012;8(5):e1002689
pubmed: 22589721
Shock. 2013 Nov;40(5):420-9
pubmed: 23903854
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Nat Rev Cardiol. 2016 Jul;13(7):404-17
pubmed: 27150190
Nutrients. 2017 Sep 06;9(9):
pubmed: 28878195
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):93-7
pubmed: 15225753
Biomolecules. 2019 Oct 24;9(11):
pubmed: 31653092
Kidney Int. 2008 Jul;74(2):170-9
pubmed: 18385669
Sci Rep. 2021 Apr 21;11(1):8570
pubmed: 33883570
Mol Med Rep. 2016 Feb;13(2):1186-94
pubmed: 26675943
Cell Commun Signal. 2019 Dec 10;17(1):163
pubmed: 31823770
Am J Respir Cell Mol Biol. 2020 Jul;63(1):79-91
pubmed: 32135073
PLoS One. 2020 Sep 17;15(9):e0239252
pubmed: 32941512
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Immunopharmacol Immunotoxicol. 2002 Aug;24(3):335-47
pubmed: 12375732
Microb Pathog. 2021 Jun;155:104930
pubmed: 33933603
Eur J Endocrinol. 2020 Nov;183(5):R133-R147
pubmed: 32755992
Nat Commun. 2015 Jan 14;6:6062
pubmed: 25585690
BMJ. 2020 Sep 4;370:m3379
pubmed: 32887691
J Biol Chem. 2004 Aug 20;279(34):35798-802
pubmed: 15205460
Mediators Inflamm. 2020 Dec 2;2020:8829674
pubmed: 33343232
J Steroid Biochem Mol Biol. 2020 Sep;202:105719
pubmed: 32535032
Nat Rev Immunol. 2017 Apr;17(4):233-247
pubmed: 28192415
Sci Rep. 2021 Dec 3;11(1):23380
pubmed: 34862422
Am J Respir Cell Mol Biol. 2017 Mar;56(3):383-392
pubmed: 27870560
Circulation. 2000 Dec 5;102(23):2867-72
pubmed: 11104746
Endocr Rev. 2012 Jun;33(3):456-92
pubmed: 22596255
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):387-92
pubmed: 15225806
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Clin Appl Thromb Hemost. 2015 Jul;21(5):428-33
pubmed: 24203351
Biochem Biophys Res Commun. 2013 Jul 19;437(1):7-11
pubmed: 23770363
Curr Opin Pharmacol. 2010 Aug;10(4):482-96
pubmed: 20427238
Endocr Rev. 2019 Aug 1;40(4):1109-1151
pubmed: 30321335
J Biol Chem. 2003 Nov 21;278(47):46862-8
pubmed: 12954644
Biochem Biophys Res Commun. 2014 Aug 15;451(1):142-7
pubmed: 25078626
J Invest Dermatol. 2012 Feb;132(2):330-6
pubmed: 21938012
J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4017-e4027
pubmed: 34097036
Int J Biochem Cell Biol. 2012 Mar;44(3):465-8
pubmed: 22155301
J Thromb Haemost. 2020 Apr;18(4):844-847
pubmed: 32073213
FASEB J. 2016 Mar;30(3):1367-76
pubmed: 26700731
J Am Soc Nephrol. 2014 Mar;25(3):564-72
pubmed: 24204002
J Clin Endocrinol Metab. 2010 Jul;95(7):3368-76
pubmed: 20427486
Lancet Respir Med. 2021 Feb;9(2):e14-e15
pubmed: 33460572
PLoS One. 2009 Jun 05;4(6):e5810
pubmed: 19503839
Eur Respir J. 2020 Oct 15;56(4):
pubmed: 32859681
Steroids. 2019 Jan;141:14-22
pubmed: 30414422
Tissue Barriers. 2018;6(4):1-13
pubmed: 30409076
JBMR Plus. 2020 Aug 22;:
pubmed: 32904944
Nutrients. 2018 Mar 26;10(4):
pubmed: 29587438
Nat Immunol. 2010 Apr;11(4):344-9
pubmed: 20208539
Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16
pubmed: 17962355
Int Immunopharmacol. 2021 Jan;90:107233
pubmed: 33290963
JAMA. 2019 Mar 12;321(10):1003-1005
pubmed: 30860552
Lancet Respir Med. 2021 Jun;9(6):622-642
pubmed: 33965003
J Clin Invest. 1984 Aug;74(2):657-61
pubmed: 6611355
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1343-e1353
pubmed: 33159440
Int J Biol Sci. 2020 Apr 21;16(11):1954-1955
pubmed: 32398962
J Transl Med. 2020 May 20;18(1):206
pubmed: 32434518
Endocrinology. 2021 Feb 1;162(2):
pubmed: 33249469
N Engl J Med. 2007 Jul 19;357(3):266-81
pubmed: 17634462
Biol Neonate. 1990;57(3-4):257-60
pubmed: 2322608
J Bone Miner Res. 2006 Jan;21(1):37-47
pubmed: 16355272
Nat Commun. 2019 Dec 18;10(1):5770
pubmed: 31852899
J Clin Invest. 2007 Mar;117(3):803-11
pubmed: 17290304
J Leukoc Biol. 2021 Jul;110(1):21-26
pubmed: 33464637
J Steroid Biochem Mol Biol. 2021 Sep;212:105928
pubmed: 34091026
Biomedicines. 2021 May 05;9(5):
pubmed: 34063015
Future Sci OA. 2020 Jul 30;6(8):FSO605
pubmed: 32974046
Sci Rep. 2015 Oct 23;5:15561
pubmed: 26494430
Nutrients. 2021 May 21;13(6):
pubmed: 34064175
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Front Immunol. 2020 Jun 09;11:1137
pubmed: 32582207
J Autoimmun. 2017 Dec;85:78-97
pubmed: 28733125
Nature. 2005 Jul 7;436(7047):112-6
pubmed: 16001071
J Virol. 2007 Jan;81(2):548-57
pubmed: 17108024
J Immunol. 2010 Aug 1;185(3):1412-8
pubmed: 20574005
J Immunol. 2004 Sep 1;173(5):2909-12
pubmed: 15322146
JCI Insight. 2020 Sep 3;5(17):
pubmed: 32706339
Nutrients. 2020 Apr 28;12(5):
pubmed: 32353972
FEBS J. 2020 Sep;287(17):3693-3702
pubmed: 32700398
Rev Med Chir Soc Med Nat Iasi. 2013 Oct-Dec;117(4):965-73
pubmed: 24502077
Nutrients. 2015 Apr 22;7(4):3011-21
pubmed: 25912039
Br J Nutr. 2014 Jan 14;111(1):23-45
pubmed: 23930771
Biochem Pharmacol. 2020 Jul;177:113955
pubmed: 32251673
Cell Death Differ. 2021 Nov;28(11):3125-3139
pubmed: 34031543
JAMA. 2021 Mar 16;325(11):1053-1060
pubmed: 33595634
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):69S-75S
pubmed: 30033760
Nat Rev Immunol. 2015 Feb;15(2):87-103
pubmed: 25614319
Respir Res. 2020 Jun 3;21(1):137
pubmed: 32493333
Signal Transduct Target Ther. 2020 Dec 11;5(1):290
pubmed: 33311438
Eur J Immunol. 2009 Nov;39(11):3147-59
pubmed: 19688742
J Endocrinol Invest. 2021 Jul 17;:
pubmed: 34273098
Clin Endocrinol (Oxf). 2021 Jun 23;:
pubmed: 34160843
Mol Med Rep. 2017 Nov;16(5):7432-7438
pubmed: 28944831
Diabetes Metab Res Rev. 2011 Nov;27(8):933-41
pubmed: 22069288
Lab Invest. 2012 Dec;92(12):1666-9
pubmed: 23191989
Mol Cell Endocrinol. 2017 Sep 15;453:52-67
pubmed: 28461074
Science. 2006 Mar 24;311(5768):1770-3
pubmed: 16497887
Metabolism. 2021 Jun;119:154753
pubmed: 33774074
EBioMedicine. 2020 Aug;58:102925
pubmed: 32745993
Nutrients. 2020 Apr 02;12(4):
pubmed: 32252338
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Eur J Immunol. 2008 Aug;38(8):2210-8
pubmed: 18651709
Lancet Diabetes Endocrinol. 2021 May;9(5):276-292
pubmed: 33798465
Invest Ophthalmol Vis Sci. 2011 Sep 21;52(10):7359-64
pubmed: 21715350
Cell Host Microbe. 2009 Sep 17;6(3):231-43
pubmed: 19748465
Pediatr Pulmonol. 2017 Jan;52(1):69-76
pubmed: 27291304
Rev Endocr Metab Disord. 2020 Mar;21(1):89-116
pubmed: 32180081
BMJ. 2017 Feb 15;356:i6583
pubmed: 28202713
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1315-1316
pubmed: 32755828
PLoS One. 2020 Sep 25;15(9):e0239799
pubmed: 32976513
PLoS Pathog. 2013;9(6):e1003407
pubmed: 23762029
Acta Med Indones. 2014 Jul;46(3):189-98
pubmed: 25348181
Science. 2020 Aug 7;369(6504):718-724
pubmed: 32661059
Ann Am Thorac Soc. 2014 May;11(4):571-7
pubmed: 24601713
J Immunol. 2003 Jun 1;170(11):5382-90
pubmed: 12759412
Nature. 2018 Jun;558(7708):136-140
pubmed: 29849149
Transl Res. 2016 Jan;167(1):183-91
pubmed: 26003524
Sci Rep. 2021 Jan 8;11(1):184
pubmed: 33420236
J Thromb Thrombolysis. 2020 Aug;50(2):278-280
pubmed: 32372336
Biochem Biophys Res Commun. 2011 Apr 22;407(4):699-702
pubmed: 21420936
J Steroid Biochem Mol Biol. 2020 Oct;203:105751
pubmed: 32871238
J Mol Med (Berl). 2006 Oct;84(10):814-20
pubmed: 16988814