Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Blood Glucose / genetics Diabetes Mellitus, Type 2 / genetics Genome-Wide Association Study / methods Genomics Humans Polymorphism, Single Nucleotide / genetics
Fine-mapping Genome-wide association study Glucose Glycaemic traits HbA1c Insulin Transethnic population

Journal

Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777

Informations de publication

Date de publication:
03 2022
Historique:
received: 02 06 2021
accepted: 21 10 2021
pubmed: 25 12 2021
medline: 1 4 2022
entrez: 24 12 2021
Statut: ppublish

Résumé

Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbA Four novel associations were identified (p < 5 × 10 Our findings provide new insights into the genetic architecture of glycaemic traits and highlight the continued importance of conducting genetic studies in diverse populations. Full summary statistics from each of the population-specific and transethnic results are available at NHGRI-EBI GWAS catalog ( https://www.ebi.ac.uk/gwas/downloads/summary-statistics ).

Identifiants

DOI: 10.1007/s00125-021-05635-9 PMID: 34951656 PMC: PMC8810722
pubmed: 34951656
doi: 10.1007/s00125-021-05635-9
pii: 10.1007/s00125-021-05635-9
pmc: PMC8810722
mid: NIHMS1769690
doi:

Substances chimiques

Blood Glucose 0

Types de publication

Journal Article Meta-Analysis Research Support, American Recovery and Reinvestment Act Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

477-489

Subventions

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Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Carolina G Downie (CG)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cdownie@live.unc.edu.
ORCID: 0000-0001-6972-9981

Sofia F Dimos (SF)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-0315-9434

Stephanie A Bien (SA)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
ORCID: 0000-0002-8713-4583

Yao Hu (Y)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
ORCID: 0000-0002-2810-646X

Burcu F Darst (BF)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0002-6205-4632

Linda M Polfus (LM)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Ambry Genetics, Aliso Viejo, CA, USA.
ORCID: 0000-0003-1123-2117

Yujie Wang (Y)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-1087-2182

Genevieve L Wojcik (GL)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0001-7206-8088

Ran Tao (R)

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-1106-2923

Laura M Raffield (LM)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-7892-193X

Nicole D Armstrong (ND)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
ORCID: 0000-0002-6483-4560

Hannah G Polikowsky (HG)

Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0001-7226-9752

Jennifer E Below (JE)

Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-6372-6402

Adolfo Correa (A)

Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
ORCID: 0000-0002-9501-600X

Marguerite R Irvin (MR)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
ORCID: 0000-0002-1442-2023

Laura J F Rasmussen-Torvik (LJF)

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
ORCID: 0000-0002-0820-7300

Christopher S Carlson (CS)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
ORCID: 0000-0003-0561-3538

Lawrence S Phillips (LS)

Atlanta VA Medical Center, Decatur, GA, USA.
Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0002-6542-8046

Simin Liu (S)

Department of Medicine, Division of Endocrinology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA.
Department of Epidemiology, Brown School of Public Health, Providence, RI, USA.
ORCID: 0000-0003-2098-3844

James S Pankow (JS)

Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
ORCID: 0000-0001-7076-483X

Stephen S Rich (SS)

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0003-3872-7793

Jerome I Rotter (JI)

Department of Pediatrics, Genome Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Steven Buyske (S)

Department of Statistics, Rutgers University, Piscataway, NJ, USA.
ORCID: 0000-0001-8539-5416

Tara C Matise (TC)

Department of Genetics, Rutgers University, Piscataway, NJ, USA.
ORCID: 0000-0002-7147-492X

Kari E North (KE)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-8903-0366

Christy L Avery (CL)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-1044-8162

Christopher A Haiman (CA)

Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0002-0097-9971

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8532-5087

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
ORCID: 0000-0002-7986-8560

Mariaelisa Graff (M)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0001-6380-1735

Heather M Highland (HM)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-3583-8239

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Multi-ethnic GWAS and fine-mapping of...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Multi-ethnic GWAS and fine-mapping of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Multi-ethnic GWAS and fine-mapping of...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Multi-ethnic GWAS and fine-mapping of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multi-ethnic GWAS and fine-mapping of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Multi-ethnic GWAS and fine-mapping of...