Anti-CD20 monoclonal antibodies inhibit seropositive response to Covid-19 vaccination in non-Hodgkin lymphoma patients within 6 months after treatment.
Journal
Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
06
07
2021
revised:
17
12
2021
accepted:
18
12
2021
pubmed:
25
12
2021
medline:
11
3
2022
entrez:
24
12
2021
Statut:
ppublish
Résumé
The Covid-19 pandemic has caused millions of deaths worldwide. Although vaccines have been developed, patients on immunosuppressive therapy are less likely to respond. This study was aimed at investigating the efficacy of a Covid-19 vaccine (Pfizer-BioNTech) in patients with non-Hodgkin lymphoma treated with anti-CD20 monoclonal antibodies. Only 1 of 28 lymphoma patients (3.6%) developed a seropositive response, compared with 100% (28/28) of the healthy volunteers. The low levels of CD19
Identifiants
pubmed: 34952139
pii: S0301-472X(21)00855-9
doi: 10.1016/j.exphem.2021.12.396
pmc: PMC8691955
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-23Informations de copyright
Copyright © 2021 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest disclosure The authors declare no competing financial interests.
Références
J Clin Exp Hematop. 2009 May;49(1):9-13
pubmed: 19474512
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Br J Haematol. 2005 Jul;130(1):96-8
pubmed: 15982350
Am J Hematol. 2021 Oct 1;96(10):1195-1203
pubmed: 34185336
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
J Clin Immunol. 2007 May;27(3):339-46
pubmed: 17345151
Blood. 2012 Aug 30;120(9):1954-7
pubmed: 22936740
Ann Rheum Dis. 2021 Oct;80(10):1355-1356
pubmed: 33958323
Blood Adv. 2021 Jun 21;5(12):2624-2643
pubmed: 34152403
Blood. 2011 Dec 22;118(26):6769-71
pubmed: 22058114