Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
HSP90 Heat-Shock Proteins
/ antagonists & inhibitors
Humans
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ metabolism
Organophosphorus Compounds
/ chemistry
Quinolones
/ chemistry
Structure-Activity Relationship
6BrCaQ
Anti-Proliferative activity
HSP90
Mitochondrial targeting
TRAP1
Triphenylphosphonium TPP
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Feb 2022
05 Feb 2022
Historique:
received:
04
10
2021
revised:
03
12
2021
accepted:
11
12
2021
pubmed:
25
12
2021
medline:
8
2
2022
entrez:
24
12
2021
Statut:
ppublish
Résumé
A series of 6BrCaQ-C
Identifiants
pubmed: 34952432
pii: S0223-5234(21)00901-6
doi: 10.1016/j.ejmech.2021.114052
pii:
doi:
Substances chimiques
3-aminoquinolein-2-one
0
Antineoplastic Agents
0
HSP90 Heat-Shock Proteins
0
Organophosphorus Compounds
0
Quinolones
0
TRAP1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114052Informations de copyright
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.