Animal models in vaccinology: state of the art and future perspectives for an animal-free approach.

Animals Models, Animal Vaccines Vaccinology

Journal

Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056

Informations de publication

Date de publication:
04 2022
Historique:
received: 26 08 2021
revised: 25 11 2021
accepted: 30 11 2021
pubmed: 26 12 2021
medline: 6 5 2022
entrez: 25 12 2021
Statut: ppublish

Résumé

Vaccine discovery and development is mainly driven by studies on immunogenicity and safety based on the appropriate animal models. In this review we will describe the importance of animal models in vaccinology, from research and development to pre-licensure and post-licensure commitments with particular emphasis on the advantages and limitations of each animal species. Finally, we will describe the most modern technologies, the new in vitro and ex vivo models and the new advances in the field which may drive into a new era of 'animal free' vaccinology.

Identifiants

DOI: 10.1016/j.mib.2021.11.014 PMID: 34953265
pubmed: 34953265
pii: S1369-5274(21)00175-2
doi: 10.1016/j.mib.2021.11.014
pii:
doi:

Substances chimiques

Vaccines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-55

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Emiliano Chiarot (E)

GSK, Siena, Italy. Electronic address: emiliano.x.chiarot@gsk.com.

Mariagrazia Pizza (M)

GSK, Siena, Italy. Electronic address: mariagrazia.x.pizza@gsk.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Animal models in vaccinology: state of the art...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Animal models in vaccinology: state of the art...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Animal models in vaccinology: state of the art...
questionsmedicales.fr › Professions de santé › Médecine › Vaccinologie › Animal models in vaccinology: state of the art...