SARS-CoV-2-specific T cell responses and immune regulation in infected pregnant women.
Immune regulation
Pregnancy
Regulatory T cells
SARS-CoV-2
T cells
Tolerogenic dendritic cells
Journal
Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
10
09
2021
revised:
17
11
2021
accepted:
10
12
2021
pubmed:
26
12
2021
medline:
2
2
2022
entrez:
25
12
2021
Statut:
ppublish
Résumé
We studied the T cell response to SARS-CoV-2 spike and non-spike peptide epitopes in eight convalescent pregnant women together with the immune monitoring that included innate tolerogenic dendritic cell populations important to maintain the immunological mother/fetus interface to address a potential risk for the antiviral cellular response in the outcome of pregnancy. Four subjects had pre-existing chronic inflammatory conditions that could have potentially affected the SARS-CoV-2-specific T cell response. Seven of eight subjects responded to SARS-CoV-2 peptides with differences within CD4+ T helper (Th) and CD8+ cytotoxic T cells (CTL). SARS-CoV-2-specific inducible regulatory T cells (iTreg) were numerous in circulation. CD4+ T cell memory included central memory T cells (T
Identifiants
pubmed: 34953325
pii: S0165-0378(21)00194-7
doi: 10.1016/j.jri.2021.103464
pmc: PMC8665650
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
103464Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR073761
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143586
Pays : United States
Organisme : NIDA NIH HHS
ID : R34 DA050341
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
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