Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses.
Adult
Aged
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
BNT162 Vaccine
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Female
Humans
Immunity, Humoral
/ immunology
Male
Middle Aged
SARS-CoV-2
/ immunology
Spike Glycoprotein, Coronavirus
/ immunology
Vaccination
/ methods
Vaccines, Synthetic
/ immunology
Young Adult
mRNA Vaccines
/ immunology
ADCC
COVID-19
Coronavirus
SARS-CoV-2
Spike glycoproteins
delayed mRNA vaccine regimen
humoral responses
neutralization
variants of concern
variants of interest
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
12 01 2022
12 01 2022
Historique:
received:
13
09
2021
revised:
08
11
2021
accepted:
29
11
2021
pubmed:
27
12
2021
medline:
27
1
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
The standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered three weeks apart. However, some public health authorities spaced these doses, raising questions about efficacy. We analyzed longitudinal humoral responses against the D614G strain and variants of concern for SARS-CoV-2 in a cohort of SARS-CoV-2-naive and previously infected individuals who received the BNT162b2 mRNA vaccine with sixteen weeks between doses. While administering a second dose to previously infected individuals did not significantly improve humoral responses, these responses significantly increased in naive individuals after a 16-week spaced second dose, achieving similar levels as in previously infected individuals. Comparing these responses to those elicited in individuals receiving a short (4-week) dose interval showed that a 16-week interval induced more robust responses among naive vaccinees. These findings suggest that a longer interval between vaccine doses does not compromise efficacy and may allow greater flexibility in vaccine administration.
Identifiants
pubmed: 34953513
pii: S1931-3128(21)00569-2
doi: 10.1016/j.chom.2021.12.004
pmc: PMC8639412
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Spike Glycoprotein, Coronavirus
0
Vaccines, Synthetic
0
mRNA Vaccines
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-109.e5Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Lancet. 2021 Jun 19;397(10292):2331-2333
pubmed: 34090624
Transfusion. 2021 May;61(5):1377-1382
pubmed: 33604922
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Lancet Reg Health Eur. 2022 Jan;12:100252
pubmed: 34729548
J Clin Lab Anal. 2017 Nov;31(6):
pubmed: 28124796
J Infect. 2021 Apr;82(4):e8-e10
pubmed: 33472093
J Virol. 2020 Aug 17;94(17):
pubmed: 32591466
J Clin Immunol. 2021 Jul;41(5):906-913
pubmed: 33725211
Nature. 2022 Apr;604(7904):141-145
pubmed: 35168246
Cell Rep. 2021 Jul 13;36(2):109353
pubmed: 34237283
J Biol Chem. 2021 Oct;297(4):101151
pubmed: 34478710
Immunity. 2021 Sep 14;54(9):2143-2158.e15
pubmed: 34453881
Science. 2021 Dec 03;374(6572):abm0829
pubmed: 34648302
N Engl J Med. 2021 Dec 9;385(24):e85
pubmed: 34706170
Infez Med. 2020 Ahead of print Jun 1;28(2):174-184
pubmed: 32275259
Science. 2020 Dec 11;370(6522):1339-1343
pubmed: 33159009
Lancet. 2021 Oct 16;398(10309):1407-1416
pubmed: 34619098
Nature. 2021 Sep;597(7878):703-708
pubmed: 34428777
N Engl J Med. 2021 Apr 22;384(16):1576-1577
pubmed: 33596348
CMAJ. 2021 Oct 25;193(42):E1619-E1625
pubmed: 34610919
Nature. 2020 Oct;586(7830):594-599
pubmed: 32998157
Sci Rep. 2021 Aug 16;11(1):16543
pubmed: 34400714
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Infect Genet Evol. 2021 Mar;88:104708
pubmed: 33421654
Cell Mol Immunol. 2021 Jul;18(7):1826-1828
pubmed: 34059791
Euro Surveill. 2021 Jan;26(3):
pubmed: 33478621
Sci Rep. 2020 Aug 20;10(1):14031
pubmed: 32820179
Virology. 2021 Nov;563:134-145
pubmed: 34536797
Immunity. 2021 Sep 14;54(9):2133-2142.e3
pubmed: 34453880
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
Cell Rep. 2022 Jan 11;38(2):110210
pubmed: 34971573
Clin Infect Dis. 2022 Nov 30;75(11):1980-1992
pubmed: 35438175
J Vet Diagn Invest. 1999 Jan;11(1):41-4
pubmed: 9925210
PLoS Med. 2006 Jul;3(7):e237
pubmed: 16796401
Cancer Biother Radiopharm. 2009 Apr;24(2):155-61
pubmed: 19409036
Nat Med. 2021 May;27(5):917-924
pubmed: 33772244
Cell. 2021 Nov 11;184(23):5699-5714.e11
pubmed: 34735795
mBio. 2020 Oct 16;11(5):
pubmed: 33067385
Science. 2022 Jan 07;375(6576):43-50
pubmed: 34812653
Lancet. 2021 Feb 6;397(10273):452-455
pubmed: 33515491
Nat Commun. 2020 Aug 13;11(1):4059
pubmed: 32792628
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Immun Ageing. 2021 Aug 20;18(1):34
pubmed: 34416887
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Nature. 2021 Aug;596(7871):276-280
pubmed: 34237773
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Cell Rep Med. 2021 Jun 15;2(6):100290
pubmed: 33969322
PLoS One. 2013 Aug 30;8(8):e72942
pubmed: 24023659
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Cell Host Microbe. 2021 Mar 10;29(3):322-324
pubmed: 33705702
Sci Transl Med. 2021 Sep;13(609):eabj0847
pubmed: 34376569
PLoS One. 2019 Mar 5;14(3):e0212893
pubmed: 30835745
Cell Rep Med. 2020 Oct 20;1(7):100126
pubmed: 33015650
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12262-12267
pubmed: 27791014
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Science. 2021 Mar 25;:
pubmed: 33766944
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
Sci Immunol. 2021 Apr 15;6(58):
pubmed: 33858945
Nature. 2021 May;593(7857):136-141
pubmed: 33706364
Nature. 2021 May;593(7858):266-269
pubmed: 33767447
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Nature. 2021 May;593(7857):130-135
pubmed: 33684923
Cell Rep. 2021 Aug 24;36(8):109570
pubmed: 34390647
MMWR Morb Mortal Wkly Rep. 2021 May 21;70(20):753-758
pubmed: 34014909
Cell Host Microbe. 2021 Jul 14;29(7):1137-1150.e6
pubmed: 34133950