Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits.
Cell proliferation
Cytokines
Interleukin-6
Stem cells
Subgranular zone
Subventricular zone
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
13
10
2021
revised:
07
12
2021
accepted:
18
12
2021
pubmed:
27
12
2021
medline:
26
4
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
Epidemiologic studies have demonstrated that infections during pregnancy increase the risk of offspring developing Schizophrenia, Autism, Depression and Bipolar Disorder and have implicated interleukin-6 (IL-6) as a causal agent. However, other cytokines have been associated with the developmental origins of psychiatric disorders; therefore, it remains to be established whether elevating IL-6 is sufficient to alter the trajectory of neural development. Furthermore, most rodent studies have manipulated the maternal immune system at mid-gestation, which affects the stem cells and progenitors in both the primary and secondary germinal matrices. Therefore, a question that remains to be addressed is whether elevating IL-6 when the secondary germinal matrices are most active will affect brain development. Here, we have increased IL-6 from postnatal days 3-6 when the secondary germinal matrices are rapidly expanding. Using Nestin-Cre
Identifiants
pubmed: 34954074
pii: S0889-1591(21)00646-2
doi: 10.1016/j.bbi.2021.12.015
pmc: PMC8885860
mid: NIHMS1767707
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-6
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-36Subventions
Organisme : NINDS NIH HHS
ID : R21 NS107772
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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