An mRNA vaccine to prevent genital herpes.
Journal
Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
30
10
2021
revised:
09
12
2021
accepted:
16
12
2021
pubmed:
27
12
2021
medline:
8
3
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
The rapid development of two nucleoside-modified mRNA vaccines that are safe and highly effective against coronavirus disease 2019 has transformed the vaccine field. The mRNA technology has the advantage of accelerated immunogen discovery, induction of robust immune responses, and rapid scale up of manufacturing. Efforts to develop genital herpes vaccines have been ongoing for 8 decades without success. The advent of mRNA technology has the potential to change that narrative. Developing a genital herpes vaccine is a high public health priority. A prophylactic genital herpes vaccine should prevent HSV-1 and HSV-2 genital lesions and infection of dorsal root ganglia, the site of latency. Vaccine immunity should be durable for decades, perhaps with the assistance of booster doses. While these goals have been elusive, new efforts with nucleoside-modified mRNA-lipid nanoparticle vaccines show great promise. We review past approaches to vaccine development that were unsuccessful or partially successful in large phase 3 trials, and describe lessons learned from these trials. We discuss our trivalent mRNA-lipid nanoparticle approach for a prophylactic genital herpes vaccine and the ability of the vaccine to induce higher titers of neutralizing antibodies and more durable CD4
Identifiants
pubmed: 34954087
pii: S1931-5244(21)00303-0
doi: 10.1016/j.trsl.2021.12.006
pmc: PMC8695322
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Lipid Nanoparticles
0
Liposomes
0
Vaccines, Synthetic
0
Viral Envelope Proteins
0
mRNA Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-65Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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