Architecture of RNA-RNA interactions.

Animals Gene Expression Regulation Mammals / genetics RNA / chemistry RNA Processing, Post-Transcriptional RNA, Untranslated RNA-Binding Proteins / genetics

Journal

Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375

Informations de publication

Date de publication:
02 2022
Historique:
received: 25 08 2021
revised: 04 11 2021
accepted: 23 11 2021
pubmed: 27 12 2021
medline: 5 4 2022
entrez: 26 12 2021
Statut: ppublish

Résumé

RNA molecules tend to form intricate tertiary structures via intramolecular RNA-RNA interactions (RRIs) to regulate transcription, RNA processing, and translation processes. In these biological processes, RNAs, especially noncoding RNAs, usually achieve their regulatory specificity through intermolecular RNA-RNA base pairing and execute their regulatory outcomes via associated RNA-binding proteins. Decoding intramolecular and intermolecular RRIs is a prerequisite for understanding the architecture of various RNA molecules and their regulatory roles in development, differentiation, and disease. Many sequencing-based methods have recently been invented and have revealed extraordinarily complicated RRIs in mammalian cells. Here, we discuss the technical advances and limitations of various methodologies developed for studying cellular RRIs, with a focus on the emerging architectural roles of RRIs in gene regulation.

Identifiants

DOI: 10.1016/j.gde.2021.11.007 PMID: 34954430
pubmed: 34954430
pii: S0959-437X(21)00140-4
doi: 10.1016/j.gde.2021.11.007
pii:
doi:

Substances chimiques

RNA, Untranslated 0
RNA-Binding Proteins 0
RNA 63231-63-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

138-144

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Yuanchao Xue (Y)

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: ycxue@ibp.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Architecture of RNA-RNA interactions.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Architecture of RNA-RNA interactions.