Biomarkers in the Degenerative Human Intervertebral Disc Tissue and Blood.
Journal
American journal of physical medicine & rehabilitation
ISSN: 1537-7385
Titre abrégé: Am J Phys Med Rehabil
Pays: United States
ID NLM: 8803677
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
pubmed:
27
12
2021
medline:
17
9
2022
entrez:
26
12
2021
Statut:
ppublish
Résumé
Patients with back pain comprise a large proportion of the outpatient practice among physiatrists. Diagnostic tools are limited to clinical history, physical examinations, and imaging. Nonsurgical treatments are largely empirical, encompassing medications, physical therapy, manual treatments, and interventional spinal procedures. A body of literature is emerging confirming elevated levels of biomarkers including inflammatory cytokines in patients with back pain and/or radiculopathy, largely because the protein assay sensitivity has increased. These biomarkers may serve as tools to assist diagnosis and assess outcomes.The presence of inflammatory mediators in the intervertebral disc tissues and blood helped to confirm the inflammatory underpinnings of back pain related to intervertebral disc degeneration. Literature reviewed here suggests that biomarkers could assist clinical diagnosis and monitor physiological outcomes during and after treatments for spine-related pain. Biomarkers must be measured in a large and diverse asymptomatic population, in the context of age and comorbidities to prevent false-positive tests. These levels can then be rationally compared with those in patients with back disorders including discogenic back pain, radiculopathy, and spinal stenosis. While studies reviewed here used "candidate marker" approaches, future nonbiased approaches in clearly defined patient populations could uncover novel biomarkers in clinical management of patients.
Identifiants
pubmed: 34954738
doi: 10.1097/PHM.0000000000001943
pii: 00002060-202210000-00012
pmc: PMC9209568
mid: NIHMS1759364
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
983-987Subventions
Organisme : RRD VA
ID : I21 RX001896
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR071623
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR078386
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.
Références
United States bone and joint initiative: the burden of musculoskeletal diseases in the United States (BMUS). 2014. Available at: https://www.boneandjointburden.org/ . Accessed January 13, 2022
Boden SD, McCowin PR, Davis DO, et al.: Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 1990;72:1178–84
Boden SD, Davis DO, Dina TS, et al.: Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 1990;72:403–8
Kepler CK, Markova DZ, Dibra F, et al.: Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs. Spine (Phila Pa 1976) 2013;38:873–80
Zhang Y, Chee A, Shi P, et al.: Intervertebral disc cells produce interleukins found in patients with back pain. Am J Phys Med Rehabil 2016;95:407–15
Shamji MF, Setton LA, Jarvis W, et al.: Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum 2010;62:1974–82
Park MS, Lee HM, Hahn SB, et al.: The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc herniation. Yonsei Med J 2007;48:839–46
Nakazawa KR, Walter BA, Laudier DM, et al.: Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration. Spine J 2018;18:343–56
Sadowska A, Touli E, Hitzl W, et al.: Inflammaging in cervical and lumbar degenerated intervertebral discs: analysis of proinflammatory cytokine and TRP channel expression. Eur Spine J 2018;27:564–77
Sadowska A, Hausmann ON, Wuertz-Kozak K: Inflammaging in the intervertebral disc. Clin Transl Neurosci 2018;2:8
Ruel N, Markova DZ, Adams SL, et al.: Fibronectin fragments and the cleaving enzyme ADAM-8 in the degenerative human intervertebral disc. Spine (Phila Pa 1976) 2014;39:1274–9
Urquhart DM, Zheng Y, Cheng AC, et al.: Could low grade bacterial infection contribute to low back pain? A systematic review. BMC Med 2015;13:13
Sadowska A, Kameda T, Krupkova O, et al.: Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity. Eur Cell Mater 2018;36:231–50
Wuertz K, Urban JP, Klasen J, et al.: Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells. J Orthop Res 2007;25:1513–22
Schroeder GD, Markova DZ, Koerner JD, et al.: Are modic changes associated with intervertebral disc cytokine profiles? Spine J 2017;17:129–34
Kang JD, Georgescu HI, McIntyre-Larkin L, et al.: Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine (Phila Pa 1976) 1996;21:271–7
Le Maitre CL, Hoyland JA, Freemont AJ: Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther 2007;9:R77
Sutovsky J, Benco M, Sutovska M, et al.: Cytokine and chemokine profile changes in patients with lower segment lumbar degenerative spondylolisthesis. Int J Surg 2017;43:163–70
Lee S, Moon CS, Sul D, et al.: Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clin Biochem 2009;42:1504–11
Bachmeier BE, Nerlich AG, Weiler C, et al.: Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha–converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. Ann N Y Acad Sci 2007;1096:44–54
Sowa GA, Perera S, Bechara B, et al.: Associations between serum biomarkers and pain and pain-related function in older adults with low back pain: a pilot study. J Am Geriatr Soc 2014;62:2047–55
Schaaf S, Huang W, Perera S, et al.: Association of protein and genetic biomarkers with response to lumbar epidural steroid injections in subjects with axial low back pain. Am J Phys Med Rehabil 2021;100:48–56
Weber KT, Satoh S, Alipui DO, et al.: Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders. Immunol Res 2015;63(1–3):170–80
Weber KT, Alipui DO, Sison CP, et al.: Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. Arthritis Res Ther 2016;18:3
Divi SN, Markova DZ, Fang T, et al.: Circulating miR-155-5p as a novel biomarker of lumbar degenerative disc disease. Spine (Phila Pa 1976) 2020;45:E499–507
Gebhardt K, Brenner H, Sturmer T, et al.: The course of high-sensitive C-reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain—a 6 months prospective longitudinal study. Eur J Pain 2006;10:711–9
Wang K, Bao JP, Yang S, et al.: A cohort study comparing the serum levels of pro- or anti-inflammatory cytokines in patients with lumbar radicular pain and healthy subjects. Eur Spine J 2016;25:1428–34
Luchting B, Rachinger-Adam B, Zeitler J, et al.: Disrupted TH 17 /Treg balance in patients with chronic low back pain. PLoS One 2014;9:e104883
Brisby H, Olmarker K, Larsson K, et al.: Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J 2002;11:62–6
Pedersen LM, Schistad E, Jacobsen LM, et al.: Serum levels of the pro-inflammatory interleukins 6 (IL-6) and -8 (IL-8) in patients with lumbar radicular pain due to disc herniation: a 12-month prospective study. Brain Behav Immun 2015;46:132–6
Cheng L, Fan W, Liu B, et al.: Th 17 lymphocyte levels are higher in patients with ruptured than non-ruptured lumbar discs, and are correlated with pain intensity. Injury 2013;44:1805–10
Schistad EI, Espeland A, Pedersen LM, et al.: Association between baseline IL-6 and 1-year recovery in lumbar radicular pain. Eur J Pain 2014;18:1394–401
Moen A, Lind AL, Thulin M, et al.: Inflammatory serum protein profiling of patients with lumbar radicular pain one year after disc herniation. Int J Inflam 2016;2016:3874964
Tian Z, Ma X, Yasen M, et al.: Intervertebral disc degeneration in a percutaneous mouse tail injury model. Am J Phys Med Rehabil 2018;97:170–7
Hill JC, Fritz JM: Psychosocial influences on low back pain, disability, and response to treatment. Phys Ther 2011;91:712–21