Sigma-1 Receptor is a Pharmacological Target to Promote Neuroprotection in the SOD1
SOD1 G93A transgenic
amyotrophic lateral sclerosis
motoneuron
neurodegenerative disease
sigma-1 receptor
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
09
2021
accepted:
08
11
2021
entrez:
27
12
2021
pubmed:
28
12
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the death of motoneurons (MNs) with a poor prognosis. There is no available cure, thus, novel therapeutic targets are urgently needed. Sigma-1 receptor (Sig-1R) has been reported as a target to treat experimental models of degenerative diseases and, importantly, mutations in the Sig-1R gene cause several types of motoneuron disease (MND). In this study we compared the potential therapeutic effect of three Sig-1R ligands, the agonists PRE-084 and SA4503 and the antagonist BD1063, in the SOD1
Identifiants
pubmed: 34955848
doi: 10.3389/fphar.2021.780588
pii: 780588
pmc: PMC8702863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
780588Informations de copyright
Copyright © 2021 Gaja-Capdevila, Hernández, Navarro and Herrando-Grabulosa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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