Case Report: No Evidence of Intracranial Fluid Shifts in an Astronaut Following an Aborted Launch.

free water (FW) hypergravity launch abort microgravity spaceflight ventricular volume

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2021
Historique:
received: 14 09 2021
accepted: 17 11 2021
entrez: 27 12 2021
pubmed: 28 12 2021
medline: 28 12 2021
Statut: epublish

Résumé

Spaceflight induces lasting enlargement of the brain's ventricles as well as intracranial fluid shifts. These intracranial fluid shifts have been attributed to prolonged microgravity exposure, however, the potential effects of hypergravity exposure during launch and landing have yet to be elucidated. Here we describe a case report of a Crewmember who experienced an Aborted Launch ("CAL"). CAL's launch and landing experience was dissociated from prolonged microgravity exposure. Using MRI, we show that hypergravity exposure during the aborted launch did not induce lasting ventricular enlargement or intracranial fluid shifts resembling those previously reported with spaceflight. This case study therefore rules out hypergravity during launch and landing as a contributing factor to previously reported long-lasting intracranial fluid changes following spaceflight.

Identifiants

pubmed: 34956056
doi: 10.3389/fneur.2021.774805
pmc: PMC8695608
doi:

Types de publication

Case Reports

Langues

eng

Pagination

774805

Informations de copyright

Copyright © 2021 McGregor, Hupfeld, Pasternak, Wood, Mulavara, Bloomberg, Hague and Seidler.

Déclaration de conflit d'intérêts

AM is employed by KBR. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Heather R McGregor (HR)

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Kathleen E Hupfeld (KE)

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Ofer Pasternak (O)

Department of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Scott J Wood (SJ)

NASA Johnson Space Center, Houston, TX, United States.

Ajitkumar P Mulavara (AP)

KBR, Houston, TX, United States.

Jacob J Bloomberg (JJ)

NASA Johnson Space Center, Houston, TX, United States.

T Nick Hague (TN)

NASA Astronaut Corps, Houston, TX, United States.

Rachael D Seidler (RD)

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.

Classifications MeSH