YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response.
YAP
inflammation
inflammatory bowel disease
mechanotransduction
rheumatoid arthritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
10
2021
accepted:
18
11
2021
entrez:
27
12
2021
pubmed:
28
12
2021
medline:
15
2
2022
Statut:
epublish
Résumé
The role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated in rheumatoid arthritis (RA). Fibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured in 2D or into 3D synovial organoids. Arthritis rat model (n=28) and colitis mouse model (n=21) were used. YAP/TAZ transcriptional activity was inhibited by verteporfin (VP). Multiple techniques were used to assess gene and/or protein expression and/or localization, cell phenotype (invasion, proliferation, apoptosis), bone erosion, and synovial stiffness. YAP/TAZ were transcriptionally active in arthritis (19-fold increase for CTGF expression, a YAP target gene, in RA Our work reveals that YAP/TAZ were critical factors during arthritis. Thus, their transcriptional inhibition could be relevant to treat inflammatory related diseases.
Identifiants
pubmed: 34956224
doi: 10.3389/fimmu.2021.791907
pmc: PMC8695934
doi:
Substances chimiques
Transcriptional Coactivator with PDZ-Binding Motif Proteins
0
YAP-Signaling Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
791907Informations de copyright
Copyright © 2021 Caire, Audoux, Courbon, Michaud, Petit, Dalix, Chafchafi, Thomas, Vanden-Bossche, Navarro, Linossier, Peyroche, Guignandon, Vico, Paul and Marotte.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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