Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG.

Biological sciences Immune response Immunology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
21 Jan 2022
Historique:
received: 19 05 2021
revised: 17 11 2021
accepted: 15 12 2021
pubmed: 28 12 2021
medline: 28 12 2021
entrez: 27 12 2021
Statut: ppublish

Résumé

Although some COVID-19 patients maintain SARS-CoV-2-specific serum immunoglobulin G (IgG) for more than 6 months postinfection, others eventually lose IgG levels. We assessed the persistence of SARS-CoV-2-specific B cells in 17 patients, 5 of whom had lost specific IgGs after 5-8 months. Differentiation of blood-derived B cells

Identifiants

pubmed: 34957380
doi: 10.1016/j.isci.2021.103659
pii: S2589-0042(21)01629-1
pmc: PMC8686444
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103659

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors have no conflicts of interests to declare.

Références

Blood. 2020 Nov 26;136(22):2588-2591
pubmed: 33001206
Cell. 2020 Nov 12;183(4):996-1012.e19
pubmed: 33010815
Nat Microbiol. 2020 Dec;5(12):1598-1607
pubmed: 33106674
N Engl J Med. 2007 Nov 8;357(19):1903-15
pubmed: 17989383
Cell. 2021 Mar 4;184(5):1201-1213.e14
pubmed: 33571429
J Immunol. 2020 Nov 1;205(9):2437-2446
pubmed: 32878912
Nature. 2021 Jul;595(7867):421-425
pubmed: 34030176
Med (N Y). 2021 Mar 12;2(3):281-295.e4
pubmed: 33589885
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Euro Surveill. 2020 Jun;25(24):
pubmed: 32583765
Annu Rev Immunol. 2021 Apr 26;39:103-129
pubmed: 33472004
Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
Science. 2020 Dec 11;370(6522):1339-1343
pubmed: 33159009
EClinicalMedicine. 2020 Dec;29:100651
pubmed: 33235985
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 32997649
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Cell. 2021 Apr 29;184(9):2384-2393.e12
pubmed: 33794143
Neurol Neuroimmunol Neuroinflamm. 2019 Oct 14;6(6):625
pubmed: 31611268
Ann Neurol. 2019 Mar;85(3):448-454
pubmed: 30635933
Nat Med. 2020 Aug;26(8):1200-1204
pubmed: 32555424
Immunity. 2020 Aug 18;53(2):248-263
pubmed: 32717182
Front Public Health. 2021 Feb 18;8:620222
pubmed: 33681115
Annu Rev Immunol. 2017 Apr 26;35:255-284
pubmed: 28142324
Cell Rep Med. 2021 Apr 20;2(4):100228
pubmed: 33748788
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33288662
Sci Immunol. 2021 Feb 23;6(56):
pubmed: 33622975
Cell. 2021 Jan 7;184(1):169-183.e17
pubmed: 33296701
J Immunol Methods. 2013 May 31;391(1-2):50-9
pubmed: 23454005
Nat Med. 2020 Nov;26(11):1691-1693
pubmed: 32929268
JCI Insight. 2020 Oct 2;5(19):
pubmed: 32870820
Immunity. 2020 Jun 16;52(6):910-941
pubmed: 32505227
Nat Immunol. 2020 Dec;21(12):1506-1516
pubmed: 33028979
Sci Transl Med. 2021 Jan 20;13(577):
pubmed: 33288661
Infection. 2021 Aug 11;:
pubmed: 34379308
Lancet. 2021 Apr 17;397(10283):1459-1469
pubmed: 33844963
Clin Infect Dis. 2021 Nov 2;73(9):e3055-e3065
pubmed: 33388756
Virol Sin. 2021 Oct;36(5):869-878
pubmed: 33661489
Nat Med. 2021 May;27(5):917-924
pubmed: 33772244
Front Immunol. 2020 Dec 18;11:610688
pubmed: 33391281
Lancet. 2021 Feb 6;397(10273):452-455
pubmed: 33515491
J Clin Invest. 2021 Apr 1;131(7):
pubmed: 33621214
PLoS One. 2020 Oct 21;15(10):e0241104
pubmed: 33085715
Front Immunol. 2021 Sep 23;12:751584
pubmed: 34630430
J Exp Med. 2011 Dec 19;208(13):2599-606
pubmed: 22162833
J Exp Med. 2004 Feb 16;199(4):593-602
pubmed: 14769849
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Immunity. 2020 Nov 17;53(5):1078-1094.e7
pubmed: 33010224
Viruses. 2020 Nov 08;12(11):
pubmed: 33171590
Lancet Infect Dis. 2020 Aug;20(8):e192-e197
pubmed: 32539990
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Front Immunol. 2021 Mar 11;12:636768
pubmed: 33777028
Cell. 2020 Nov 25;183(5):1298-1311.e11
pubmed: 33125897
Eur J Immunol. 2011 Jun;41(6):1800-8
pubmed: 21469123
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
Cell Rep. 2021 Mar 23;34(12):108890
pubmed: 33713594
Eur J Immunol. 2009 May;39(5):1260-70
pubmed: 19404981
Sci Immunol. 2020 Dec 22;5(54):
pubmed: 33443036
Annu Rev Immunol. 2005;23:367-86
pubmed: 15771575
J Immunol. 2020 Nov 1;205(9):2342-2350
pubmed: 32887754
Nature. 2008 Sep 25;455(7212):532-6
pubmed: 18716625
Immunity. 2021 Feb 9;54(2):205-210
pubmed: 33513337
Nat Commun. 2021 Feb 8;12(1):844
pubmed: 33558507
J Infect Dis. 2021 Dec 01;:
pubmed: 34865053
Nat Commun. 2020 Sep 17;11(1):4704
pubmed: 32943637
Immunol Rev. 2010 Jul;236:125-38
pubmed: 20636813
Science. 2021 Mar 25;:
pubmed: 33766944
mBio. 2020 Sep 25;11(5):
pubmed: 32978311
JAMA. 2021 Feb 9;325(6):529-531
pubmed: 33404586
J Clin Invest. 2021 Apr 1;131(7):
pubmed: 33571162

Auteurs

Stephan Winklmeier (S)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Katharina Eisenhut (K)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Damla Taskin (D)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Heike Rübsamen (H)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Ramona Gerhards (R)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Celine Schneider (C)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Paul R Wratil (PR)

Max von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.

Marcel Stern (M)

Max von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.

Peter Eichhorn (P)

Institute of Laboratory Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.

Oliver T Keppler (OT)

Max von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.

Matthias Klein (M)

Department of Neurology, University Hospital, LMU Munich, 81377 Munich, Germany.

Simone Mader (S)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Tania Kümpfel (T)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Edgar Meinl (E)

Institute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Martinsried, Germany.

Classifications MeSH