GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome.
GWAS
SNP
enteric nervous system
genetics
gut motility
irritable bowel syndrome
peristalsis
polygenic scores
Journal
Cell genomics
ISSN: 2666-979X
Titre abrégé: Cell Genom
Pays: United States
ID NLM: 9918284260106676
Informations de publication
Date de publication:
08 Dec 2021
08 Dec 2021
Historique:
received:
13
08
2020
revised:
27
07
2021
accepted:
11
10
2021
entrez:
27
12
2021
pubmed:
28
12
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the number of bowel movements per day, based on questionnaire data) as a proxy for gut motility in a GWAS meta-analysis including 167,875 individuals from UK Biobank and four smaller population-based cohorts. We identify 14 loci associated with stool frequency (p ≤ 5.0 × 10
Identifiants
pubmed: 34957435
doi: 10.1016/j.xgen.2021.100069
pii: S2666-979X(21)00085-9
pmc: PMC8654685
doi:
Types de publication
Journal Article
Langues
eng
Pagination
NoneSubventions
Organisme : Wellcome Trust
ID : 202802/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
A.R. is a founder and equity holder of Celsius Therapeutics, an equity holder in Immunitas Therapeutics, and, until August 31, 2020, was a scientific advisory board member of Syros Pharmaceuticals, Neogene Therapeutics, Asimov, and Thermo Fisher Scientific. A.R. is a member of the journal advisory board. From August 1, 2020, A.R. is an employee of Genentech.
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