Loss of function mutations of

Animals Hodgkin Disease / pathology Humans Loss of Function Mutation Mice Mutation Polycomb Repressive Complex 1 / metabolism Proto-Oncogene Proteins / genetics Reed-Sternberg Cells / pathology Repressor Proteins / genetics
BCOR Classical Hodgkin lymphoma PRC1 Polycomb microdissection

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
05 2022
Historique:
pubmed: 28 12 2021
medline: 26 5 2022
entrez: 27 12 2021
Statut: ppublish

Résumé

BCOR is a component of a variant Polycomb repressive complex 1 (PRC1.1). PRC1 and PRC2 complexes together constitute a major gene regulatory system critical for appropriate cellular differentiation. The gene is upregulated in germinal center (GC) B cells and mutated in a number of hematologic malignancies. We report

Identifiants

DOI: 10.1080/10428194.2021.2015587 PMID: 34957890
pubmed: 34957890
doi: 10.1080/10428194.2021.2015587
doi:

Substances chimiques

BCOR protein, human 0
Bcor protein, mouse 0
Proto-Oncogene Proteins 0
Repressor Proteins 0
Polycomb Repressive Complex 1 EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1080-1090

Subventions

Organisme : NCI NIH HHS
ID : R01 CA071540
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220499
Pays : United States

Auteurs

Maciej Giefing (M)

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.
ORCID: 0000-0002-4760-8246

Micah D Gearhart (MD)

Department of Genetics, Cell Biology and Development, Masonic Cancer Center and Developmental Biology Center, University of Minnesota, Minneapolis, USA.

Markus Schneider (M)

Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany, and Deutsches Konsortium für Translationale Krebsforschung (DKTK).
Department of Pediatric Hematology and Oncology, University Children's Hospital Essen, Essen, Germany.

Birte Overbeck (B)

Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.

Wolfram Klapper (W)

Department of Pathology, Haematopathology Section and Lymph Node Registry, Christian-Albrechts University Kiel, Kiel, Germany.

Sylvia Hartmann (S)

Reference and Consultant Center of Lymph Node and Lymphoma Pathology at Dr. Senckenberg Institute of Pathology, University of Frankfurt, Medical School, Frankfurt, Germany.

Adam Ustaszewski (A)

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Marc A Weniger (MA)

Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany, and Deutsches Konsortium für Translationale Krebsforschung (DKTK).

Laura Wiehle (L)

Institute of Human Genetics, University of Ulm and University of Ulm Medical Center, Ulm, Germany.

Martin-Leo Hansmann (ML)

Reference and Consultant Center of Lymph Node and Lymphoma Pathology at Dr. Senckenberg Institute of Pathology, University of Frankfurt, Medical School, Frankfurt, Germany.

Ari Melnick (A)

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, USA.

Wendy Béguelin (W)

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, USA.

Christer Sundström (C)

Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.

Ralf Küppers (R)

Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany, and Deutsches Konsortium für Translationale Krebsforschung (DKTK).

Vivian J Bardwell (VJ)

Department of Genetics, Cell Biology and Development, Masonic Cancer Center and Developmental Biology Center, University of Minnesota, Minneapolis, USA.

Reiner Siebert (R)

Institute of Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.
Institute of Human Genetics, University of Ulm and University of Ulm Medical Center, Ulm, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Loss of function mutations of
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Maladie de Hodgkin › Loss of function mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of function mutations of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Loss of function mutations of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Loss of function mutations of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Loss of function mutations of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-1 › Loss of function mutations of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Loss of function mutations of
questionsmedicales.fr › Cellules › Cellules de Reed-Sternberg › Loss of function mutations of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Loss of function mutations of