What 'Omics can tell us about antifungal adaptation.
Candida albicans
Candida glabrata
Saccharomyces cerevisiae
'Omics
antifungals
resistance
Journal
FEMS yeast research
ISSN: 1567-1364
Titre abrégé: FEMS Yeast Res
Pays: England
ID NLM: 101085384
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
received:
04
10
2021
accepted:
22
12
2021
pubmed:
28
12
2021
medline:
1
2
2022
entrez:
27
12
2021
Statut:
ppublish
Résumé
Invasive candidiasis, the most frequent healthcare-associated invasive fungal infection, is commonly caused by Candida albicans. However, in recent years other antifungal-resistant Candida species-namely Candida glabrata and Candidaauris-have emerged as a serious matter of concern. Much of our understanding of the mechanisms regulating antifungal resistance and tolerance relies on studies utilizing C. albicans, C. glabrataand the model yeast Saccharomyces cerevisiae. 'Omics studies have been used to describe alterations in metabolic, genomic and transcriptomic expression profiles upon antifungal treatment of fungal cells. The physiological changes identified by these approaches could significantly affect fungal fitness in the host and survival during antifungal challenge, as well as provide further understanding of clinical resistance. Thus, this review aims to comparatively address 'omics data for C. albicans, C. glabrata andS. cerevisiae published from 2000 to 2021 to identify what these technologies can tell us regarding cellular responses to antifungal therapy. We will also highlight possible effects on pathogen survival and identify future avenues for antifungal research.
Identifiants
pubmed: 34958354
pii: 6484793
doi: 10.1093/femsyr/foab070
pmc: PMC8755904
pii:
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Aberdeen
Organisme : BBSRC
Organisme : Academy of Medical Sciences
ID : SBF006\1128
Pays : United Kingdom
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.
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